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Breast cancer (BC) is a heterogeneous disease whose histopathological and molecular characteristics significantly affect the clinical outcome of patients
Breast cancer (BC) is a heterogeneous disease whose histopathological and molecular characteristics significantly affect the clinical outcome of patients
Bone is the most common metastasis site of BC, but there is no relevant biomarker for predicting bone metastasis of disease
In this study, the researchers aimed to identify gene signatures associated with the onset of bone metastasis (BM) in circulating tumor cells (CTC) , which were isolated from 40 patients with metastatic BC through a DEPArray-based protocol, and based on the disease The metastasis sites are divided into groups, namely BM group (bone metastasis only), ES group (extra-bone metastasis) or BM+ES group (bone+extra-bone metastasis)
Researchers aim to identify gene signatures associated with the pathogenesis of bone metastasis (BM) in circulating tumor cells (CTC) Researchers aim to identify gene signatures associated with the pathogenesis of bone metastasis (BM) in circulating tumor cells (CTC)
Targeted RNAseq reveals gene expression profiles related to metastasis sites
Targeted RNAseq reveals gene expression profiles related to metastasis sitesResearchers have developed a targeted RNAseq detection method to screen for genes closely related to the metastatic cascade
Researchers have developed a targeted RNAseq detection method to screen for genes closely related to the metastatic cascade
Comparative analysis of functional enrichment of down-regulated genes
Comparative analysis of functional enrichment of down-regulated genesThe researchers further applied this set of data to the CTC group, especially the comparison between the BM group and the ES group
The researchers identified 31 differentially expressed genes, including MAF, CAPG, GIPC1 and IL1B, which play a key prognostic role in BC
Correlation between targeted RNAseq signature of breast cancer CTCs and onset of bone-only metastases.
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