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It is well known that the tumor micro-environment consists of a variety of elements that affect the adaptability of tumor cells, and oxygen, as a key element of tumor micro-environment, plays a vital role in the patient's prognostics.
Clinical studies have found that hypoxia tumor tissue is significantly worse in treatment than oxygen-rich tumor tissue, but oxygen, as a known selective pressure, favors certain types of aggressive cancer cells that can withstand harsh environments and metascess from their native environments.
Previous studies have shown that hypoxia is associated with tumor metastasis, and although multiple mechanisms have been proposed to explain the phenomenon, it is not yet known whether it is the result of a precise mechanism as a key cause or a combination of mechanisms.
tumor evolution can not only promote the development of cancer and improve resistance to tumor treatment through genetic and metaphysical mutations, but also through the selection of interactions between tumor cells, normal cells and physical micro-environments.
In this study, the researchers used a combination of mathematical models and histology to analyze the effects of oxygen-deficulated regions on cell cloning formation relative to the oxygen-free region by simulating cell proliferation capabilities under different oxygen utilization conditions, and to analyze whether increased tumor cell stress would accelerate tumor evolution.
the heterogeneity of necrotic and TP53 expression regions in tissues by dyeing compared to tissue samples from patients with glioblastoma.
results show that cell division levels in low-oxygen environments are effectively raised, indicating that low-oxygen environments provide a way for tumor cells to spread.
same human tissue data analysis showed that cell division did not decrease under hypoxia conditions, consistent with the above results.
that low oxygen conditions may be effective in affecting the rate of tumor evolution, increasing the likelihood of key mutations.
, important tumor microencology ( such as low oxygen status ) may change the rate at which tumors evolve, drive tumor mutations and exacerbate tumor heterogeneity.
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