Br J Cancer: LncRNA HOTAIR promotes the invasion and metastasis of prostate cancer by targeting hepaCAM.

Prostate cancer (PCa) is one of the most common malignancies in men, and most cases are diagnosed with metastatic late stages due to mild and hidden early symptoms.
the current treatment of PCa has made a lot of progress, docetaxel is not effective in improving the prognostics of tumor metastasis patients.
more and more studies have been conducted to assess the effectiveness of dossythals and other drugs.
, studying potential mechanisms to promote PCa transfer will help identify new prognosios markers or therapeutic targets for the disease.
with the development of tumor transcriptomics, long non-coded RNA (lncRNA) has been shown to be associated with tumor development and metastasis.
and some abnormally expressed lncRNAs have been identified in PCa cell line and clinical samples, which may play a key role in the pathogenesis of PCa.
lncRNA HOTAIR (HOX transcription anthotic RNA) has been found to play a vital role in the development and metastasis of tumors.
, however, how it facilitates the transfer and invasion of the PCa remains unclear.
HOTAIR was highly expressed in prostate cancer and associated with H3K27me3 and hepaCAM levels In this study, the relationship between HOTAIR and hepaCAM (hepatocellular adhesion molecule) in PCa was identified by immunogrouping, immunofluorescence, real-time fluorescence quantitative PCR, and immunoprinting.
the regulation of HOTIR to hepaCAM and MAPK signal transducting paths and its key role in PCa transfer.
knock-out OFIR significantly reduced the invasive and metastasis of PCa cells, and researchers found that in the blood and tissues of PCa patients, HOTAIR expression levels were negatively associated with hepaCAM.
, hepaCAM has been identified as a new target gene for HOTIR, which is critical to the invasiveness of PCa.
further studies have shown that HOTAIR induces abnormal activation of high-level H3K27me3 modifications and MAPK paths by raising PRC2 to the hepaCAM promoter, ultimately inhibiting the expression of hepaCAM.
knocking out HOTIRR and inhibiting the expression of EZH2 can induce the re-expression of hepaCAM by inhibiting the MAPK signal transducting path, and weaken the invasive and transfer capability of PCa cells.
, the study shows that HOTAIR can promote PCa invasive and metastasis by reducing the inhibition of hepaCAM on the MAPK signal transducting path.
, the HOTAIR/hepaCAM/MAPK path path may be a potential target for the treatment and prognosmation of advanced prostate cancer.
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