Br J Cancer: Migrastatic: Potential anti-metastatic therapy for metastatic melanoma

Metastasis is a major sign of cancer and the main cause of death from most cancers
.

However, due to the complexity of its underlying mechanisms and the difficulty in defining clinical endpoints, metastatic cancers are also difficult to target

Metastasis is a major sign of cancer and the main cause of death from most cancers

The development of the drug depends on the perfection of approval regulations and extensive screening of compounds that are generally less toxic but have high efficacy on the spread of cancer cells
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Preclinical metastasis models also greatly benefit from corresponding strategies to visualize cancer cells in vivo and quantitatively track their spread to evaluate the preclinical efficacy of metastatic drugs

In this study, the researchers performed bioinformatics analysis on a publicly available melanoma database
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And through in vitro target verification, a new type of traceable spontaneous metastatic melanoma model was developed for in vivo verification, and the drug effect of tumor tissue was confirmed through histological experiments

And through in vitro target verification, and through in vitro target verification, a new type of traceable spontaneous metastatic melanoma model was developed for in vivo verification, and the drug effect of tumor tissue was confirmed through histological experiments

Schematic diagram of preclinical development of a new migrastatic migration drug

Schematic diagram of preclinical development of a new migrastatic migration drug

The results of bioinformatics analysis identified the ROCK-myosin II pathway and its components as potential targets for melanoma
.

The researchers found that several RhoGEF upstream of RhoA are redundant, and ROCK has been identified as a drug-therapeutic target downstream of RhoA

The results of bioinformatics analysis identified the ROCK-myosin II pathway and its components as potential targets for melanoma

Identify genes involved in the occurrence and development of melanoma through the cancer patient database

Identify genes involved in the occurrence and development of melanoma through the cancer patient database

All in all, the study puts forward a model for Migrastatic drug development
.

The researchers used a new type of traceable spontaneous melanoma metastasis model to quantify cancer metastasis and the anti-metastatic effects of drugs in vivo through non-invasive imaging techniques

This study puts forward a model for Migrastatic drug development

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

 

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