Br J Cancer: Research on Non-invasive Diagnosis Strategy of Gastric Cancer Based on the Features of Blood Transcriptomics

Gastric cancer (GC) is the second leading cause of cancer-related deaths in the world.
In the United States, almost one-third of GC patients are in the advanced stage of distant metastasis at the time of diagnosis, and the 5-year survival rate of these patients is less than 30%
.

Gastric cancer (GC) is the second leading cause of cancer-related deaths in the world.
In the United States, almost one-third of GC patients are in the advanced stage of distant metastasis at the time of diagnosis, and the 5-year survival rate of these patients is less than 30%
.

Gastric cancer (GC) is the second leading cause of cancer-related deaths in the world.

Many factors, including tumor heterogeneity, limited treatment options, and insufficient response to conventional treatments, all contribute to the poor prognosis of the disease
.

In addition, the lack of clinically available non-invasive screening methods is still one of the most critical obstacles to improving the outcome of this malignant disease

Screening

At present, endoscopy is considered to be the standard for screening and diagnosis of the disease
.

However, endoscopy is a relatively expensive and invasive procedure with rare but serious complications

The invasive nature of

9 gene evaluation to distinguish the public gene expression data set of gastric cancer and adjacent normal tissues

9 gene evaluation to distinguish the public gene expression data set of gastric cancer and adjacent normal tissues

The results showed that the researchers identified a 9-gene evaluation system during the discovery phase, and then verified it in tissue samples
.

By analyzing the serum training cohort, the researchers developed a 5-gene risk prediction formula for diagnosing GC, with an AUC (area under the ROC curve) of 0.
896

The 5-gene biomarker evaluation system was verified by an independent serum cohort, and the AUC value obtained was 0.

947

Organizational verification of 9-gene evaluation system in clinical cohort

Organizational verification of 9-gene evaluation system in clinical cohort

All in all, the study mainly identified a new 5-gene biomarker evaluation system for non-invasive diagnosis of GC, which may be used as a potential diagnostic tool for early detection of the disease
.

The study mainly identified a new 5-gene biomarker evaluation system for non-invasive diagnosis of GC, which may be used as a potential diagnostic tool for early detection of the disease
.

The study mainly identified a new 5-gene biomarker evaluation system for non-invasive diagnosis of GC, which may be used as a potential diagnostic tool for early detection of the disease

A blood-based transcriptomic signature for noninvasive diagnosis of gastric cancer.

 

Leave a message here