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Br J Cancer: Research on related gene mutations in tumor adjacent tissues, plasma and saliva reveals the evolutionary process of head and neck squamous cell carcinoma recurrence

 Last Update: 2021-08-01
 Source: Internet
 Author: User

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Head and neck cancer is one of the most common and deadly malignant tumors in the world.
Head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of all head and neck cancers
.

Previous studies have shown thatthere is a causal relationship betweenhuman papillomavirus (HPV) infection and oropharyngeal cancer

Head and neck cancer is one of the most common and deadly malignant tumors in the world.

However, in the Chinese population, the HPV-16 infection rate only accounts for 7.
0% of all HNSCC cases
.

Smoking and continuous drinking are the highest risk factors for HPV-16-negative (HPV-) HNSCC patients, and their survival rate is worse than that of HPV-16-positive (HPV+) HNSCC patients

The researchers identified somatic mutations in 188 matched samples through second-generation sequencing.
These samples included primary tumors, tumor adjacent tissues (TAT), preoperative and postoperative plasma, saliva, and peripheral blood from 27 patients Lymphocytes (PBL) samples, and analyzed the evolutionary relationship between TAT and tumors, and monitored the dynamic changes of tumors and TAT-specific mutations in liquid biopsy and survival analysis
.

Somatic mutation information in HNSCC patients

The results showed that the researchers detected 27 and 19 mutations in 27 tumor tissue samples and 26 TAT samples, respectively
.

TP53 is the most common mutant gene in TAT

Postoperative disease recurrence monitoring in patients with HNSCC

It is worth noting that the TP53 mutation in TAT is closely related to the patient's precancerous transformation, and corresponds to a poor survival period (hazard ratio=14.
01)
.

Further research found that TAT-specific mutations were also detected in preoperative and/or postoperative liquid biopsies, indicating the recurrence of the disease

The TP53 mutation in TAT is closely related to the patient's precancerous transformation, and corresponds to a poor survival period (hazard ratio=14.

The genomic architectures of tumour-adjacent tissues, plasma and saliva reveal evolutionary underpinnings of relapse in head and neck squamous cell carcinoma.

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