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    Home > Active Ingredient News > Antitumor Therapy > Br J Cancer: Sodium ion concentration in breast cancer predicts tumor malignancy and treatment response

    Br J Cancer: Sodium ion concentration in breast cancer predicts tumor malignancy and treatment response

    • Last Update: 2022-05-20
    • Source: Internet
    • Author: User
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    Metastatic breast cancer is one of the leading causes of cancer-related deaths in women worldwide, and the triple-negative breast cancer subtype corresponds to a poorer prognosis for patients
    .
    Current standard-of-care strategies for the disease include X-rays, ultrasound, magnetic resonance imaging (MRI), and biopsy
    .
    The addition of additional MRI
    diagnostics to care strategies may improve patient outcomes through early diagnosis, assessment of tumor structure and morphology, and monitoring of response to treatment
    .
    Therefore, novel non-invasive MRI biomarkers are urgently needed to improve clinical outcomes of patients

    .

    Metastatic breast cancer is one of the leading causes of cancer-related deaths in women worldwide, and the triple-negative breast cancer subtype corresponds to a poorer prognosis for patients
    .
    Metastatic breast cancer is one of the leading causes of cancer-related deaths in women worldwide, and the triple-negative breast cancer subtype corresponds to a poorer prognosis for patients
    .
    Breast Cancer Diagnosis

    Previous studies have shown that, unlike traditional proton-based imaging techniques, non-invasive 23 Na MRI based on intratumoral sodium ion concentration (Na + ) may be a biomarker for breast cancer .

    In this study, the researchers aimed to explore the diagnostic and therapeutic monitoring potential of Na MRI in preclinical models of breast cancer
    .

    Unlike traditional proton-based imaging techniques, non-invasive 23 Na MRI based on intratumoral sodium ion concentration (Na + ) may be a biomarker for breast cancer .

    Unlike traditional proton-based imaging techniques, non-invasive 23 Na MRI based on intratumoral sodium ion concentration (Na + ) may be a biomarker for breast cancer .

    + 23 23


    The researchers selected female Rag2 -/- , Il2rg -/- , and Balb/c mice bearing orthotopic breast tumors (MDA-MB-231, EMT6, and 4T1), and analyzed them by MRI, ex vivo fluorescence microscopy, and electrophysiology.
    Detect corresponding tumor biological indicators

    .


    -/- -/-


    23Na MRI showed elevated Na + concentration in xenograft tumors


    23 Na MRI showed elevated Na + concentration in xenograft tumor 23 +

    23 Na MRI results showed that the sodium ion concentration (Na + ) in the tumor was significantly higher than that in the non-tumor area
    .
    Complementary proton-based diffusion-weighted imaging (DWI) correlates elevated Na+with corresponding cellular structures
    .
    Imaging techniques combined with 23Na MRI and DWI enabled an excellent classification accuracy of tumor and non-tumor regionscompared to either of the above parameters alone
    .

    23 Na MRI results showed that the sodium ion concentration (Na + ) in the tumor was significantly higher than that in the non-tumor area
    .
    23 Na MRI results showed that the sodium ion concentration (Na + ) in the tumor was significantly higher than that in the non-tumor area
    .
    23++23


    Further studies revealed that ex vivo tumor section assessment confirmed elevated intracellular Na + concentrations, while extracellular remained unchanged
    .
    Treatment with specific Na
    + exchange inhibitors (cariporide, eslicarbazepine acetate) did not affect intratumoral Na + concentrations
    .
    Nonetheless, the researchers found that docetaxel was effective in reducing Na
    + concentrations in tumors, but there was no significant change in DWI measurements
    .


    + + + +


    Docetaxel reduces maximum 23 Na signal in xenografts


    Docetaxel reduces the maximum 23Na signal in xenografts23

    In conclusion, the results of this study show that abnormally elevated Na + concentrations can be detected in an orthotopic breast cancer model
    .
    In addition,
    23 Na MRI imaging technology can enhance the diagnostic power of DWI with higher sensitivity, which may serve as a potential non-invasive biomarker of disease malignancy and treatment response
    .

    The + 23 Na MRI imaging technique can enhance the diagnostic power of DWI with higher sensitivity, which may serve as a potential non-invasive biomarker of disease malignancy and treatment response
    .
    23Na MRI imaging technology can enhance the diagnostic power of DWI with higher sensitivity, which may serve as a potential non-invasive biomarker of disease malignancy and treatment response
    .
    twenty three


    Original source:


    Original source:

    James, AD, Leslie, TK, Kaggie, JD et al.
    Sodium accumulation in breast cancer predicts malignancy and treatment response.
    Br J Cancer (25 April 2022).

    James, AD, Leslie, TK, Kaggie, JD et al.
    Sodium accumulation in breast cancer predicts malignancy and treatment response.
    Br J Cancer (25 April 2022).

    https://doi.
    org/10.
    1038/s41416-022-01802-w.

    https://doi.
    org/10.
    1038/s41416-022-01802-w.


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