Metastatic breast cancer is one of the leading causes of cancer-related deaths in women worldwide, and the triple-negative breast cancer subtype corresponds to a poorer prognosis for patients
.
Current standard-of-care strategies for the disease include X-rays, ultrasound, magnetic resonance imaging (MRI), and biopsy
.
The addition of additional MRI diagnostics to care strategies may improve patient outcomes through early diagnosis, assessment of tumor structure and morphology, and monitoring of response to treatment
.
Therefore, novel non-invasive MRI biomarkers are urgently needed to improve clinical outcomes of patients
.
.
Metastatic breast cancer is one of the leading causes of cancer-related deaths in women worldwide, and the triple-negative breast cancer subtype corresponds to a poorer prognosis for patients
.
Breast Cancer Diagnosis
Previous studies have shown that, unlike traditional proton-based imaging techniques, non-invasive 23 Na MRI based on intratumoral sodium ion concentration (Na + ) may be a biomarker for breast cancer .
In this study, the researchers aimed to explore the diagnostic and therapeutic monitoring potential of Na MRI in preclinical models of breast cancer
.
Unlike traditional proton-based imaging techniques, non-invasive 23 Na MRI based on intratumoral sodium ion concentration (Na + ) may be a biomarker for breast cancer .
+ 23 23
The researchers selected female Rag2 -/- , Il2rg -/- , and Balb/c mice bearing orthotopic breast tumors (MDA-MB-231, EMT6, and 4T1), and analyzed them by MRI, ex vivo fluorescence microscopy, and electrophysiology.
Detect corresponding tumor biological indicators
.
-/- -/-
23Na MRI showed elevated Na + concentration in xenograft tumors
23 Na MRI showed elevated Na + concentration in xenograft tumor 23 +
23 Na MRI results showed that the sodium ion concentration (Na + ) in the tumor was significantly higher than that in the non-tumor area
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Complementary proton-based diffusion-weighted imaging (DWI) correlates elevated Na+with corresponding cellular structures
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Imaging techniques combined with 23Na MRI and DWI enabled an excellent classification accuracy of tumor and non-tumor regionscompared to either of the above parameters alone
.
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23 Na MRI results showed that the sodium ion concentration (Na + ) in the tumor was significantly higher than that in the non-tumor area
.
23++23
Further studies revealed that ex vivo tumor section assessment confirmed elevated intracellular Na + concentrations, while extracellular remained unchanged
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Treatment with specific Na + exchange inhibitors (cariporide, eslicarbazepine acetate) did not affect intratumoral Na + concentrations
.
Nonetheless, the researchers found that docetaxel was effective in reducing Na + concentrations in tumors, but there was no significant change in DWI measurements
.
+ + + +
Docetaxel reduces maximum 23 Na signal in xenografts
Docetaxel reduces the maximum 23Na signal in xenografts23
In conclusion, the results of this study show that abnormally elevated Na + concentrations can be detected in an orthotopic breast cancer model
.
In addition, 23 Na MRI imaging technology can enhance the diagnostic power of DWI with higher sensitivity, which may serve as a potential non-invasive biomarker of disease malignancy and treatment response
.
.
23Na MRI imaging technology can enhance the diagnostic power of DWI with higher sensitivity, which may serve as a potential non-invasive biomarker of disease malignancy and treatment response
.
twenty three
Original source:
Original source:
James, AD, Leslie, TK, Kaggie, JD et al.
Sodium accumulation in breast cancer predicts malignancy and treatment response.
Br J Cancer (25 April 2022).
Sodium accumulation in breast cancer predicts malignancy and treatment response.
Br J Cancer (25 April 2022).
https://doi.
org/10.
1038/s41416-022-01802-w.
org/10.
1038/s41416-022-01802-w.
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