Br J Cancer: The level of estrogen in urine can be used as a risk indicator for the development of prostate cancer

Prostate cancer (PCa) is the second most common cancer among men worldwide.

Therefore, the study aims to explore the correlation between the level of estrogen in urine and the clinical outcome of patients.

The researchers collected urine samples from patients before radical prostatectomy (RP) in the prospective multi-institution PROCURE cohort, and set up a discovery cohort (n=259) and a verification cohort (n=253) two cohort studies .

The biotransformation model of estrogen and its related derivatives

The results showed that the median follow-up time for the discovery and verification cohorts were 7.

Correlation of estrogen in urine of patients with prostate cancer

All in all, the results of the study revealed that the levels of estriol and 16-ketoestradiol metabolites in urine are associated with a more favorable outcome for patients, while the level of 2-methoxyestrone is associated with the risk of metastasis after RP.