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Br J Cancer: The prognostic and diagnostic significance of neutrophil lymphocyte ratio NLR in hepatocellular carcinoma

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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The main prognostic clinical features of hepatocellular carcinoma (HCC) include tumor size and number, appearance of vascular infiltration, serum alpha-fetoprotein (AFP) level, performance status, and neutrophil-lymphocyte ratio (NLR)
.

Blood vessel

NLR is a hypothetical indicator that measures the balance between neutrophil-related tumor-promoting inflammatory response and lymphocyte-dependent anti-tumor immune function, and has been considered as a prognostic factor for many cancers including HCC
.

In this study, the researchers followed a prospective cumulative cohort of 781 patients (493 HCC patients and 288 chronic liver disease (CLD) patients without HCC) for more than 6 years
.

By comparing the NLR levels between HCC patients and CLD patients, and using a multivariate Cox regression model to evaluate the impact of baseline NLR on the overall survival rate of HCC patients

The results showed that there was no clinically significant difference in the baseline NLR value between CLD patients and HCC patients
.

Among HCC patients, the NLR level at the last visit before follow-up/death was significantly higher than baseline

Kaplan-Meier Survival Curve Analysis of HCC Patients

All in all, the results of the study revealed that NLR is an important independent prognostic factor affecting the survival of HCC patients
.

NLR is an important independent prognostic factor that affects the survival of HCC patients
.

NLR is an important independent prognostic factor that affects the survival of HCC patients

The prognostic and diagnostic significance of the neutrophil-to-lymphocyte ratio in hepatocellular carcinoma: a prospective controlled study.

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