Br J Cancer: TriCurin, a new phytochemical mixture, inhibits the growth of cervical cancer cells

Although some progress has been made in the study of cervical cancer, human papillomavirus (HPV) continues to cause significant morbidity and mortality, with 570,000 cases and 311,000 deaths worldwide in 2018.
surgery and ablation are the only effective options in the event of precanceral cervical lesions.
, however, these treatment strategies increase the likelihood of adverse complications during future pregnancies.
previous studies have shown that the phytochemical mixture TriCurin (curcubin, EGCG and resveratrol) eliminates HPV-positive cancer cells.
the study, the researchers aimed to further evaluate TriCurin.
TriCurin and its monosomes inhibited the growth of precanceral lesions W12 cells using experimental techniques such as MTT and RT-PCR to determine the activity of TriCurin and its monosome compounds in W12 cells derived from cervical cancer derived from free and integrated HPV16 DNA.
the stability and toxicity of TriCurin micro-emulsions in organ-type cervical tissue models.
the growth inhibition of TriCurin and Dansan ketone IIA combined, the researchers found that TriCurin and its monosome compounds inhibited the growth of free, integrated type 1 and integrated type 2 W12 cells.
relative activity were TriCurin, EGCG, curcub and resveratrol.
RT-PCR results show that p53 can be activated in W12 cells treated with TriCurin and inhibit HPV16 mRNA E1, E2, E4, E6 and E7.
gene expression analysis showed that TriCurin was able to activate the apoptosis gene in HeLa cells and inhibit the anti-apoptosis gene.
further studies have shown that TriCurin in micro-emulsions is stable and non-toxic to cervical tissue.
combination of TriCurin and tanshinone IIA shows additional synergy for HeLa cells.
, the results showed that a combination of TriCurin and TriCurin and dansin ketone IIA was effective in resisting HPV cells.
therefore, emulsions containing the plant chemical mixture micro-emulsions may be potential therapeutic agents for the prevention and treatment of cervical cancer.
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