Br J Dermatol: Incidence of acute complications of shingles in immune-competent adults in the UK

Background: Shingles can cause rare but serious complications, and the frequency of these complications has not been well described
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Objective: To quantify the risk of post-acute non-shingles neuralgia (PHN) herpes zoster complications, and to provide a basis for formulating vaccination strategies
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Method: We use health data routinely collected from the British clinical practice research data link (2001-2018) to treat immune-immune adults who have not been vaccinated against shingles and non-belts matching their age, gender and behavior.
A control group of adults with herpes underwent a cohort study
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The original attributable risk of complications was estimated as the difference between the cumulative incidence of shingles patients estimated by Kaplan-Meier and the control group at 3 months

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Results: A total of 178964 cases of shingles and 1799380 control cases were included
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The absolute risk of herpes zoster-specific complications within 3 months after the diagnosis of herpes zoster is: Ramsay Hunt syndrome 0-37% [95%CI 0.

34-0.

Ramsay Hunt syndrome disseminated herpes zoster herpes zoster death herpes zoster hospitalized neurological complications ocular complications skin complications visceral complications

Table 1 The overall and age-specific risk of complications in patients with herpes zoster attributable to herpes zoster within 3 months after herpes zoster (95% confidence interval); ^a Kaplan-Meier method was used to calculate the total percentage, as Determine the cumulative incidence of each main outcome in the exposed group and the unexposed group at 3 months;

Table 1 The overall and age-specific risk of complications in patients with herpes zoster attributable to herpes zoster within 3 months after herpes zoster (95% confidence interval); ^a Kaplan-Meier method was used to calculate the total percentage, as Determine the cumulative incidence of each major outcome in the exposed and unexposed groups at 3 months; ^a

The difference in cumulative incidence is attributable to risk; ^b does not include Ramsay Hunt syndrome or post-herpetic neuralgia; ^c does not include disseminated herpes zoster
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The difference in cumulative incidence is attributable to risk; ^b does not include Ramsay Hunt syndrome or post-herpetic neuralgia; ^c does not include disseminated herpes zoster
.
^{b c}

Table 2 Correlation between non-post-herpetic neuralgia complications and the use of antiviral drugs within 3 months after the diagnosis of herpes zoster (patients with herpes zoster with good immune function are unlikely to receive antiviral drug treatment in the hospital) ( n=175 800)

Table 2 Correlation between non-post-herpetic neuralgia complications and the use of antiviral drugs within 3 months after the diagnosis of herpes zoster (patients with herpes zoster with good immune function are unlikely to receive antiviral drug treatment in the hospital) ( n=175 800)

Conclusion: The non-PHN complications of shingles are relatively common, which may affect the cost-effectiveness calculation of shingles vaccination

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In addition to causing PHN, shingles may also cause various complications

Original source

 Forbes HJ, Bhaskaran K, Grint D, et al, Incidence of acute complications of herpes zoster among immunocompetent adults in England: a matched cohort study using routine health data.

Incidence of acute complications of herpes zoster among immunocompetent adults in England: a matched cohort study using routine health data.
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