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In recent years, the role of intestinal signals in the pathogenesis of neuropsychiatric disorders has received great attention.
In recent years, the role of intestinal signals in the pathogenesis of neuropsychiatric disorders has received great attention.
In the journal Immunity , the vagus nerve is involved in microbial reduction of some important aspects of depression-like behaviors after fecal microbiota transplantation (FMT) in Chrna7 knockout (KO) mice receiving a depressive phenotype .
The α-7 nicotinic acetylcholine receptor (α7 nAChR , encoded by the Chrna7 gene ) is expressed in the brain and several immune cells of our body, and is believed to play an important role in the etiology of neuropsychiatric diseases such as anxiety and depression.
Pu et al.
Another feature of this research is to investigate the potential value of the genetic and protein composition of these specific transplanted microorganisms, which can provide valuable insights into the molecular interactions between these organisms and the host immune system, which lead to anxiety and depression.
Recently, studies have shown that in human patients with recurrent Clostridium difficile colitis, FMT is a mature, safe and effective treatment method, with a reported success rate of up to 90% .
Finally, since the normal intestinal flora to maintain normal immune response to the normal intestinal flora of the maintenance of normal immune responses ( ( including mucosal immunity including mucosal immunity ) ) is important, it is important, the FMT the FMT intestinal microbiota The change may have an impact on several aspects of the immune response and have an impact on subsequent health conditions.
Original source:
1.
1.
2.
ncbi.
nlm.
nih.
gov/33766699/" target="_blank" rel="noopener">Munshi, Soumyabrata.
“A depressed gut makes for a depressed brain via vagal transmission.
” ncbi.
nlm.
nih.
gov/33766699/" target="_blank" rel="noopener"> Munshi, Soumyabrata.
“A depressed gut makes for a depressed brain via vagal transmission.
” ncbi.
nlm.
nih.
gov/33766699/" target="_blank" rel="noopener">Brain, behavior, and immunity , S0889-1591(21 ) 00119-7 22 Mar.
2021, doi:.
10.
1016 / j.
bbi.
2021.
03.
017 Brain, behavior, and Immunity
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