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In an unedited manuscript study recently published in the journal Nature
, researchers assessed brain changes associated with severe acute respiratory syndrome coronavirus (SARS-CoV-2) in British (UK) Biobank patients .
Smell and taste symptoms have been reported to precede the onset of pulmonary coronavirus disease 2019 ( COVID-19 ) symptoms
Nature COVID-19
Brain Injury Research
Brain Injury ResearchIn the current observational study, researchers assessed brain abnormalities in 587 UK residents aged 51-81 who underwent brain imaging twice over a three-year period as part of a UK Biobank analysis
.
Of these, 401 participants were diagnosed with COVID-19 between scans
Diagnose infection
Image-derived phenotypes (IDPs) were obtained and assessed with the help of brain scans
.
Each IDP represents an aspect of brain function or structure
statistics
Findings and Discussion:
Findings and Discussion:A total of 2,047 reproducible brain IDPs were obtained, of which 297 covered the olfactory area
.
Of these, the eight most important IDPs cover brain regions associated with the primary olfactory cortex
Testicular Injury Research
Testicular Injury ResearchA previous study reported testicular pain in patients with COVID-19
.
An autopsy study of men who died of COVID-19 showed orchitis with extensive testicular cell damage, but SARS-CoV-2 was not consistently found in semen samples
The HKU team investigated testicular and hormonal changes in hamsters infected with influenza virus via the intranasal or direct testicular route in a control group
.
The study found that hamsters infected with the virus developed self-limiting pneumonia
Analysis conclusion:
Analysis conclusion:The findings highlight the deleterious effects of COVID-19 on the brain and testis, with consistent and modest microstructural changes in cortical thickness and mean diffusivity
.
These changes were mainly seen in the limbic and brain olfactory systems
prevention
references:
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM.
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM.
Can Li, Zhanhong Ye, Anna Jin-Xia Zhang, Jasper Fuk-Woo Chan, Wenchen Song, Feifei Liu, Yanxia Chen, Mike Yat-Wah Kwan, Andrew Chak-Yiu Lee, Yan Zhao, Bosco Ho-Yin Wong, Cyril Chik -Yan Yip, Jian-Piao Cai, David Christopher Lung, Siddharth Sridhar, Dongyan Jin, Hin Chu, Kelvin Kai-Wang To and Kwok-Yung Yuen, Accepted, Clinical Infectious Diseases.
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