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    Home > Active Ingredient News > Study of Nervous System > Brain: Glial fibrillary acidic protein and neurofilament light chain levels 8 months after brain trauma predict brain structural changes 5 years later

    Brain: Glial fibrillary acidic protein and neurofilament light chain levels 8 months after brain trauma predict brain structural changes 5 years later

    • Last Update: 2022-05-24
    • Source: Internet
    • Author: User
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    There is great interest in the possibility of progressive neurological deterioration due to traumatic brain injury
    .
    Although blood biomarkers such as glial fibrillary acidic protein and neurofilament light have been widely used to characterize acute traumatic brain injury, their use in the chronic phase has been limited

    .
    Given growing evidence that these proteins may be markers of persistent neurodegeneration in a range of diseases

    .

    There is great interest in the possibility of progressive neurological deterioration due to traumatic brain injury
    .
    Although blood biomarkers such as glial fibrillary acidic protein and neurofilament light have been widely used to characterize acute traumatic brain injury, their use in the chronic phase has been limited

    .
    Given growing evidence that these proteins may be markers of persistent neurodegeneration in a range of diseases

    .

    Virginia FJ Newcombe et al.
    published a research article in BRAIN titled Post-acute blood biomarkers and disease progression in traumatic brain injury, examining the relationship between glial fibrillary acidic protein and neurofilament light chain levels in months to years after traumatic brain injury Relationship between imaging changes and functional outcomes

    .

    Virginia FJ Newcombe et al.
    published a research article in BRAIN titled Post-acute blood biomarkers and disease progression in traumatic brain injury, examining the relationship between glial fibrillary acidic protein and neurofilament light chain levels in months to years after traumatic brain injury Relationship between imaging changes and functional outcomes

    .

    The research team recruited 203 patients in two different cohorts; six months post-injury (n=165); and >5 years post-injury (n=38; 12 of them also provided 8 months post-TBI data)
    .
    Subjects underwent blood biomarker sampling (n=199) and magnetic resonance imaging (n=172; including diffusion tensor imaging)

    .

    The research team recruited 203 patients in two different cohorts; six months post-injury (n=165); and >5 years post-injury (n=38; 12 of them also provided 8 months post-TBI data)
    .
    Subjects underwent blood biomarker sampling (n=199) and magnetic resonance imaging (n=172; including diffusion tensor imaging)

    .

    Data from the patient cohort were compared with 59 healthy volunteers and 21 non-brain trauma trauma controls
    .
    The mean diffusivity and fractional anisotropy of cortical gray matter, deep gray matter, and whole-brain white matter were calculated

    .

    Data from the patient cohort were compared with 59 healthy volunteers and 21 non-brain trauma trauma controls
    .
    The mean diffusivity and fractional anisotropy of cortical gray matter, deep gray matter, and whole-brain white matter were calculated

    .

    Gray matter (Panel A) and white matter (Panel B) VBM results of patients and controls more than 5 years after traumatic brain injury
    .

    Gray matter (Panel A) and white matter (Panel B) VBM results of patients and controls more than 5 years after traumatic brain injury
    .

    Whole brain gray matter and whole brain white matter in subgroups of patients who showed improvement (1 point increase in GOSE), stable (no change in GOSE), or worsening (1 point decrease in GOSE) between 8 months and 5 years after injury (Fig.
    A and B) and predicted brain age differences in GFAP and NFL levels (Panels C and D)

    .

    Whole brain gray matter and whole brain white matter in subgroups of patients who showed improvement (1 point increase in GOSE), stable (no change in GOSE), or worsening (1 point decrease in GOSE) between 8 months and 5 years after injury (Fig.
    A and B) and predicted brain age differences in GFAP and NFL levels (Panels C and D)

    .

    The study found:

    The study found:
    1. Elevated serum neurofilament light chain concentrations in the early stages of chronicity
      .
      Although glial fibrillary acidic protein (GFAP) values ​​were within the normal range at 8 months, many patients exhibited significant secondary and transient elevations more than 5 years after injury

      .
    2. Elevated biomarkers at 6 months were significantly associated with indicators of microstructural damage on diffusion tensor imaging
      .
    3. Biomarker levels at approximately 8 months predicted a reduction in white matter volume after 5 years, and an annualized reduction in brain volume from 8 months to 5 years
      .
    4. Patients with functional deterioration between 8 months and 5 years exhibited higher than expected brain age and elevated neurofilament light chain levels
      .
  • Elevated serum neurofilament light chain concentrations in the early stages of chronicity
    .
    Although glial fibrillary acidic protein (GFAP) values ​​were within the normal range at 8 months, many patients exhibited significant secondary and transient elevations more than 5 years after injury

    .
  • Elevated serum neurofilament light chain concentrations in the early stages of chronicity
    .
    Although glial fibrillary acidic protein (GFAP) values ​​were within the normal range at 8 months, many patients exhibited significant secondary and transient elevations more than 5 years after injury

    .
  • Elevated biomarkers at 6 months were significantly associated with indicators of microstructural damage on diffusion tensor imaging
    .
  • Elevated biomarkers at 6 months were significantly associated with indicators of microstructural damage on diffusion tensor imaging
    .
  • Biomarker levels at approximately 8 months predicted a reduction in white matter volume after 5 years, and an annualized reduction in brain volume from 8 months to 5 years
    .
  • Biomarker levels at approximately 8 months predicted a reduction in white matter volume after 5 years, and an annualized reduction in brain volume from 8 months to 5 years
    .
  • Patients with functional deterioration between 8 months and 5 years exhibited higher than expected brain age and elevated neurofilament light chain levels
    .
  • Patients with functional deterioration between 8 months and 5 years exhibited higher than expected brain age and elevated neurofilament light chain levels
    .

    In conclusion, this study demonstrates that glial fibrillary acidic protein and neurofilament light chain levels can remain elevated for months to years after traumatic brain injury, showing a distinct temporal distribution
    .
    These elevations were closely associated with microstructural damage in both gray and white matter in simultaneous quantitative diffusion tensor imaging

    .
    Neurofilament light chain elevation at approximately 8 months predicts persistent white matter and brain volume loss after 5 years

    .
    If confirmed, these findings suggest that
    later blood biomarker levels could be used to identify traumatic brain injury survivors who are at high risk for progressive neurological damage
    .

    In conclusion, this study demonstrates that glial fibrillary acidic protein and neurofilament light chain levels can remain elevated for months to years after traumatic brain injury, showing a distinct temporal distribution
    .
    These elevations were closely associated with microstructural damage in both gray and white matter in simultaneous quantitative diffusion tensor imaging

    .
    Neurofilament light chain elevation at approximately 8 months predicts persistent white matter and brain volume loss after 5 years

    .
    If confirmed, these findings suggest that
    later blood biomarker levels could be used to identify traumatic brain injury survivors who are at high risk for progressive neurological damage
    .
    After traumatic brain injury, glial fibrillary acidic protein and neurofilament light chain levels can remain elevated for months to years and show distinct temporal distributions
    .
    These elevations were closely associated with microstructural damage in both gray and white matter in simultaneous quantitative diffusion tensor imaging

    .
    Elevated neurofilament light chain at approximately 8 months predicts persistent white matter and brain volume loss beyond 5 years After
    traumatic brain injury, glial fibrillary acidic protein and neurofilament light chain levels can remain elevated for months to years.
    increased and showed a clear temporal distribution

    .
    These elevations were closely associated with microstructural damage in both gray and white matter in simultaneous quantitative diffusion tensor imaging

    .
    Neurofilament light chain elevation at approximately 8 months predicts persistent white matter and brain volume loss beyond 5 years.
    Later blood biomarker levels can be used to identify traumatic brain injury survivors at high risk for progressive neurological damage
    .
    Later blood biomarker levels can be used to identify traumatic brain injury survivors at high risk for progressive neurological damage
    .

    original source

    original source

    Virginia FJ Newcombe, Nicholas J.
    Ashton, Jussi P.
    Posti, Ben Glocker, Anne Manktelow, Doris A.
    Chatfield, Stefan Winzeck, Edward Needham, Marta M.
    Correia, Guy B.
    Williams, Joel Simrén, Riikka SK Takala, Ari J .
    Katila, Henna-Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K.
    Menon, Post-acute blood biomarkers and disease progression in traumatic brain injury, 
    Brain , 2022;, awac126,  https: https://doi.
    org/10.
    1093/brain/awac126

    Virginia FJ Newcombe, Nicholas J.
    Ashton, Jussi P.
    Posti, Ben Glocker, Anne Manktelow, Doris A.
    Chatfield, Stefan Winzeck, Edward Needham, Marta M.
    Correia, Guy B.
    Williams, Joel Simrén, Riikka SK Takala, Ari J .
    Katila, Henna-Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K.
    Menon, Post-acute blood biomarkers and disease progression in traumatic brain injury, 
    Brain , 2022;, awac126,  https: //doi.
    org/10.
    1093/brain/awac126
    Brain https://doi.
    org/10.
    1093/brain/awac126


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