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    Home > Food News > Food Articles > Brain organoids develop optic cups that respond to light

    Brain organoids develop optic cups that respond to light

    • Last Update: 2021-08-26
    • Source: Internet
    • Author: User
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    On August 17, a study published in Cell Stem Cell, a journal of Cell Press, showed that human induced pluripotent stem cells (iPSCs) can be used to generate optic cups (a structure in the eye).


    "Our work emphasizes the remarkable ability of brain organoids to produce primitive sensory structures, which are light-sensitive and contain cell types similar to those of the human body


    Many aspects of human brain development and diseases can be studied with 3D brain-like organs derived from pluripotent stem cells.


    But in the past, the use of pluripotent stem cells to derive optic cups was mainly for the production of retina


    In order to achieve this goal, Gopalakrishnan and the team modified their previously developed solution for transforming iPSCs into neural tissue


    Using 16 independent batches of iPSCs from 4 donors, the researchers generated 314 brain organoids, 72% of which formed optic cups, indicating that the method is reproducible


    Gopalakrishnan said: "In the mammalian brain, the nerve fibers of retinal ganglion cells extend outward to connect with their brain targets, but this has never been demonstrated in an in vitro system


    In future research, scientists plan to develop a strategy to enable the optic cup to survive for a long time, so as to study the mechanism of inducing retinal diseases


    Related paper information: https:// href="https://" target="_blank">https://

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