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    Home > Active Ingredient News > Study of Nervous System > Brain- Plasma glial fibrillary acidic protein, which can reflect Alzheimer’s amyloid changes

    Brain- Plasma glial fibrillary acidic protein, which can reflect Alzheimer’s amyloid changes

    • Last Update: 2021-08-03
    • Source: Internet
    • Author: User
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    There is increasing evidence that the pathogenesis of Alzheimer's disease (AD) is not limited to amyloid beta (Aβ) plaques and tau tangles, but also includes strong interactions with immunological mechanisms
    .
    In response to this, astrocytic reactivity or astrocytosis is a well-known pathological process that is usually found around Aβ plaques in the brains of AD patients


    .


    immunity


    Compared with the relationship between astrocytosis and Aβ plaques, the relationship between reactive astrocytes and tau tangles has been less studied
    .
    A few existing evaluation studies have shown that reactive astrocytes also interact with tau entanglement, but only in the late stage of AD through the penetration of extracellular ghost tau entanglement


    .


    Compared with the relationship between astrocytosis and Aβ plaques, the relationship between reactive astrocytes and tau tangles has been less studied



    They identified 217 persons with Aβ-negative cognitive impairment, 71 persons with Aβ-positive cognitive impairment, 78 persons with Aβ-positive cognitive impairment, 63 persons with Aβ-negative cognitive impairment and 75 persons with non-cognitive impairment from the Swedish BioFINDER-2 study.
    The levels of astrocyte markers in plasma and cerebrospinal fluid (CSF) of patients with AD neurodegenerative diseases


    .



    They found that compared with subjects without Aβ lesions, plasma GFAP concentrations in all Aβ-positive groups were significantly increased (P <0.
    01)


    .


    Compared with subjects without Aβ lesions, the plasma GFAP concentrations of all Aβ-positive groups were significantly increased (P <0.


    Compared with plasma GFAP, the concentration of CSF GFAP in non-AD patients was significantly higher than that in other groups (p <0.


    05) , and it was only associated with Aβ-PET in patients with Aβ-positive cognitive impairment (p = 0.
    005)
    .


    Compared with plasma GFAP, the CSF GFAP concentration of non-AD patients was significantly higher than that of other groups (p <0.
    05).


    Plasma GFAP is an early marker related to brain Aβ pathology, but not tau aggregation.


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