Brain: Sleep disorders related to impaired brain microcirculation may indicate early signs of Parkinson's disease

Rapid eye movement sleep phase (REM) sleep behavior disorder (RBD) is a parasomnia, which is characterized by dream interpretation or dream-playing behavior when the state of reduced muscle tone disappears during REM sleep
.

The severity of RBD's dream interpretation behavior ranges from benign hand movements to violent arm swings, punches and kicks

Rapid eye movement sleep phase (REM) sleep behavior disorder (the RBD) is a different state of sleep, which is characterized characterized in characterized in that in the REM the REM muscle during sleep tension disappears reduced state, acts or dream interpretation occurs Called dream-playing behavior

In the case of spontaneous occurrence, RBD is the case of α- spontaneous occurrence, and RBD is a precursor syndrome

In the general population and the elderly, the prevalence of RBD is 0.

5%-1% and 2%, respectively

In the general population and the elderly, the prevalence of RBD is 0.

In published case series studies, RBD is significantly more common in men (male to female ratio is as high as 9:1) RBD is significantly more common in males (male to female ratio is as high as 9:1) , but female cases may be underreported And missed diagnosis

In PD , and the other [alpha] - related disease synuclein PD prodromal period, neurodegeneration is thought to gradually affect the deep brain nuclei, such as the ventricles, the dorsal raphe nucleus, substantia nigra forebrain and Meynert basal ganglia
.

In addition to participating in the regulation of mood, sleep, behavior and memory function, these nuclei still dominates the entire cerebral cortex of arterial and capillary blood vessels , may be adjusted in order to ensure the supply of oxygen necessary neural activity

In PD , and the other [alpha] - related disease synuclein PD prodromal period, neurodegeneration is thought to gradually affect the deep brain nuclei, such as the ventricles, the dorsal raphe nucleus, substantia nigra forebrain and Meynert basal ganglia

Recently, experts from the Center for Functional Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Denmark , conducted related research in order to evaluate whether patients with isolated RBD show microvascular flow disorders consistent with central blood flow control disorders

Dynamic susceptibility contrast MRI was used to describe 20 polysomnographic-confirmed solitary RBD patients ( 17 men, age 54-77 years) and 25 healthy matched controls ( 25 men, age 58-76 years) ) The microscopic distribution of cerebral blood flow in the cerebral cortex
.

The patients and the control group underwent cognitive tests through the Montreal Cognitive Assessment ( MoCA ) and Mini Mental State Examination (MMSE) .

Dynamic susceptibility contrast MRI was used to describe 20 polysomnographic-confirmed solitary RBD patients ( 17 men, age 54-77 years) and 25 healthy matched controls ( 25 men, age 58-76 years) ) The microscopic distribution of cerebral blood flow in the cerebral cortex

The results showed that compared with the control group, the patient's entire cerebral cortex had severe hypoperfusion and microvascular flow disorders

At the same time, researchers have observed that abnormal cortical blood flow in RBD patients may be related to impaired neurogenic control and the degree of cognitive dysfunction
.
They hypothesized that the use of drugs to restore neurotransmitter levels around blood vessels can help maintain the cognitive function of patients with this PD precursor phenotype
.

Meanwhile, the researchers observed, RBD RBD cortex in patients with impaired blood flow abnormalities may be associated with neurogenic control, and is associated with the degree of cognitive impairment
.
They hypothesized that the use of drugs to restore neurotransmitter levels around blood vessels could help maintain the abnormal cortical blood flow in
such patients, which may be related to impaired neurogenic control and the degree of cognitive dysfunction .
Abnormal cortical blood flow in patients may be related to impaired neurogenic control and the degree of cognitive dysfunction
.
Cognitive function of patients with PD prodromal phenotype
.

In summary, patients with rapid eye movement sleep behavior disorder have changes in blood flow in the brain, which may lead to hypoxia in the brain tissue
.
In the long run, this may lead to symptoms of Parkinson's disease
.

In summary, patients with rapid eye movement sleep behavior disorder have changes in blood flow in the brain, which may lead to hypoxia in the brain tissue
.
In the long run, this may lead to symptoms of Parkinson's disease
.
In summary, patients with rapid eye movement sleep behavior disorder have changes in blood flow in the brain, which may lead to hypoxia in the brain tissue
.
In the long run, this may lead to symptoms of Parkinson's disease
.

 

  

references:

references:

Impaired cerebral microcirculation in isolated REM sleep behaviour disorder , Brain, Volume 144, Issue 5, May 2021, Pages 1498–1508, https://doi.
org/10.
1093/brain/awab054

Isolated cerebral Microcirculation in the REM impaired SLEEP Behavior disorder , Brain, Volume 144, Issue.
5, On May 2021, Pages 1498-1508, https://doi.
org/10.
1093/brain/awab054 impaired cerebral Microcirculation in the REM SLEEP Isolated Behavior disorder here message