BRAIN: The effects of dopamine on intensive learning in Parkinson's disease depend on motor-induced power generation

Parkinson's disease is clinically defined as slow movement, stiffness and tremors.
, the severity of these motor signs varies widely from individual to individual, especially in the presence or not of tremors.
changes in tremors are associated with changes in cognitive/motivational disorders, as well as spatial distribution of neurodegeneration in the central brain and dopamine consumption in the stria.
here, researchers try to clarify whether the heterogeneity of the individual with tremor symptoms can explain the inexplicable magnitude of the mutation in the effects of dopamine-energy drugs, a basic cognitive function dependent on dopamine.
Given that people with shock-based and non-tremor-based Parkinson's disease have different dopamine-energy ideomorphs, the researchers hypothesically assume that dopamine-energy drugs have different effects on intensive learning in patients with tremor-based and non-tremor-based patients. The
study recruited 43 patients with predominantly Parkinson's disease and 20 non-tremor patients to test for the shutdown and opening of dopamine-energy drugs (200/50 mg L-Doba-sacin), respectively, and 22 age-matching control groups to conduct two shutdown tests.
participants performed an intensive learning task designed to distinguish between the impact of learning rates and the impact on motivational choices (i.e., the tendency to "go/not go" in the face of the threat of rewards/threats).
in non-tremor patients, dopamine-based drugs improved reward-based choices, repeating previous studies.
, dopamine-based drugs improved punitive learning in patients with tremors.
formal modeling showed that dopamine drugs had different computational effects on the ideomorphism of Parkinson's disease, and adjusted the motivational bias and learning rate of non-tremor and tremor patients respectively.
findings establish new cognitive/motivational differences between tremor and non-tremor Parkinson's patients and emphasize the importance of considering exercise esomoria in future work.
origins: Annelies J van Nuland, Rick C Helmich, Michiel F Dirkx, Effects of dopamine on learning in Parkinson's disease on motor on phenotype MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual.
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