Brain’s new discovery: people with migraine are three times more likely to get depression than ordinary people?

It is understood that people with migraine are three times more likely to suffer from bipolar disorder or depression than the general population, and vice versa
.

But the clinical overlap between schizophrenia and migraine has not been well described

People with migraine are three times more likely to suffer from bipolar disorder or depression than the general population, and vice versa

The shared genetic basis has led to the overlap of the phenotypic and pathological etiology observed between migraine and mental illness

At the same time, the currently comprehensive genome-wide association study ( GWAS ) has proved that about half of the total heritability of each disease is caused by common genetic mutations
.

And GWAS also identified 38, 30, 102 and 176 genetic risk sites for migraine, bipolar disorder, depression and schizophrenia

GWAS and GWAS also identified 38, 30, 102 and 176 genetic risk sites for migraine, bipolar disorder, depression and schizophrenia, respectively

In order to better determine the degree of overlap between the polygene structure of migraine and bipolar disorder, depression and schizophrenia beyond the genetic correlation, and to determine the shared gene locus, led by a psychiatric specialist from Oslo University Hospital, Norway A study was carried out and the results were published in the latest "Brain" magazine
.

The summary statistics of the genome-wide association study come from a large-scale joint study of migraine (n=59674; control=316078), bipolar disorder (n=20352; control=31358), depression (n=170756; control= 328443) and schizophrenia (n=40675, control=64643)
.

The binary causal mixed model is used to estimate the variance of the influence disorder shared between migraine and each mental disorder, and the condition/connection error discovery rate method is used to identify the common sites

Univariate MiXeR analysis showed that compared with mental disorders (8.
1K-12.
3K), the polygenic (2.
8K) variants of migraine were significantly reduced
.

Bivariate analysis estimates that there are 0.

There are 0.

The researchers identified 14 loci associated with the combination of migraine and depression and 36 loci associated with the combination of migraine and schizophrenia, and the researchers identified 14 loci associated with the combination of migraine and depression And 36 loci associated with migraine and schizophrenia,

At the same time, functional annotation maps 37 and 298 genes to each of migraine, depression and schizophrenia, including several new putative migraine genes, such as L3MBTL2, CACNB2, SLC9B1
.

Genomic analysis identified several putative genomes rich in localized genes, including transmembrane transport in migraine and schizophrenia

It can be seen that most of the genetic variants that affect migraine will affect the occurrence of depression and schizophrenia
.

It can be seen that most of the genetic variants that affect migraine will affect the occurrence of depression and schizophrenia
.

It can be seen that most of the genetic variants that affect migraine will affect the occurrence of depression and schizophrenia

references:

Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools , Brain, 2021;, awab267, https://doi.
org/10.
1093/brain/awab267

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