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Guide: Salmonella typhoid in poisonous mice will become a promising biological agent in cancer co-treatment.
years, tumor-targeted microorganisms have become tumor-specific drug delivery vectors or therapeutic agents, such as kaka-Miao bacteria, anaerobic bacteria, tumor-soluble viruses and so on.
because of the low oxygen, immunosuppression, and unique biochemical microenvirasts in solid tumors, these bacteria can be implanted in tumor tissues, " he said.
it is understood that certain types of bacteria can be delivered to tumors by near-infrared (NIR) absorbents for photoheating.
however, light therapy or photoimmune therapy using bacteria alone is not currently possible without adding other therapeutic agents or nanoparticles.
August 14th, a study published in Science Advances broke through the bottleneck and proposed a photoimmune therapy that uses bacteria entirely.
A team of researchers from Suzhou University found that the detoxifying salmonella, after intravenous injection, proliferates in various types of solid tumors, causing inflammation that triggers thrombosis in infected tumors by destroying the tumor's blood vessels, thus helping the tumor to melt effectively.
, bacterial-triggered photohealtherapy can induce an effective anti-tumor immune response.
DOI: 10.1126/sciadv.aba3546 specifically, the researchers first determined the distribution of detoxifying salmonella in mice.
they found that within 72 hours of the injection, the bacteria were gradually removed from major organs such as the heart, liver, spleen, kidneys and lungs.
contrast, the formation units (CFUs) in tumors increase exponentially over time.
addition, after tracking the bacteria's long-term behavior in normal organs in mice, the researchers found that after 30 days, almost no bacterial infections were found in the organs of mice.
, the researchers need to determine the safety of this detoxifying salmonella.
results of a hematological examination showed that acute inflammation caused by detoxifying salmonella was tolerated in mice and recovered within a week without chronic toxicity.
the above results showed that the detoxifying salmonella was stored in tumors with high biosecurity-specificity after injection at a test dose.
to determine safety, the researchers then examined the effects of detoxifying salmonella on tumors.
they found that significant blood vessel dissolution and thrombosis were observed in tumor slices in mice injected with bacteria.
, the hemoglobin content in the tumor site increased significantly after the bacteria were injected.
these results show that the cultivation of detoxifying salmonella in tumors can trigger tumor-specific thrombosis by destroying tumor blood vessels.
and this effect leads to strong tumor-specific near-infrared absorption, thus achieving effective photoheat ablation of tumors.
bacterial-triggered tumor photoheat ablation finally, the researchers looked at the immune response of bacteria-triggered photohealth therapy to ablation of tumors in mice.
they found that these bacteria can act as immune stimulators, enhancing the systemic anti-tumor immune response triggered by tumor-related antigens produced by photoheat therapy to ablate tumors. in addition,
bacterial-induced photohealth immunotherapy, with the help of anti-CTLA-4 checkpoint blocking therapy, bacterial-based photohealtherapy can effectively inhibit the growth and spontaneous tumor metastasis of distant tumors, while providing long-term immune memory effects to protect mice from recurrent tumors.
researchers stress that these effects of typhoid salmonella in poisonous mice will make it a promising biological agent in joint cancer treatment.
is that salmonella typhoid has been clinically tested, making this bacterial-based treatment easy to convert clinically.
.