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    Home > Active Ingredient News > Endocrine System > [Breakthrough] How can the obesity problem be effectively solved?

    [Breakthrough] How can the obesity problem be effectively solved?

    • Last Update: 2021-11-14
    • Source: Internet
    • Author: User
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    This article is original by Translational Medicine Network.
    Please indicate the source for reprinting.
    Author: Tiffany Guide: Obesity is a state of excessive accumulation of fat in the body
    .

    When the human body eats more calories than consumes, the excess calories are stored in the body in the form of fat, which exceeds the normal physiological requirement, and when it reaches a certain value, it becomes obesity
    .

    The weight of adipose tissue in normal male adults accounts for 15% to 18% of body weight, and females account for 20% to 25%
    .

    With age, the proportion of body fat increases accordingly
    .

    It causes diseases such as hypothalamic disease, pituitary disease, Cushing syndrome, hypothyroidism and so on
    .

    Recently, a group of scientists conducted research on improving obesity.
    .
    .
    A study published in "The Lancet Children and Adolescent Health" showed that the arteries and blood vessels of obese adolescents have already begun to change in their teens.
    Got stiff
    .

    Xu Zhimin, deputy chief physician of the Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, said: “Arterial stiffness has long ceased to appear in middle-aged and elderly people
    .

    ” In recent years, the trend of arteriosclerosis has become more and more obvious, and these people Among them, obese people are the main ones, and children, adolescents and young people are the groups with the fastest rising obesity rate
    .

    However, this is only one of the disadvantages that obesity brings to people's health.
    Obesity has many adverse effects on people.
    For example, the degree of obesity is closely related to the mortality rate.
    As the degree of obesity increases, the mortality rate also rises sharply; Because of obesity, fat will adhere to the surface of the heart, reducing the contractile function of the heart, leading to a large increase in the proportion of heart failure; obesity is like a shadow with diabetes, the incidence of diabetes in obese people is 4 times higher than that of ordinary people; fatty liver and The incidence of dyslipidemia is very high in China.
    About 10% of fatty liver patients will progress to steatohepatitis, leading to liver cirrhosis or liver cancer
    .

    Therefore, the scientific community has always been very concerned about how to help people solve the problem of obesity
    .

    Recently, scientists at the University of Texas Southwestern have discovered a safe and effective method that is similar to the benefits of a plant compound in the treatment of obesity
    .

    Although this new method has certain side effects, this new discovery has key significance and very important enlightenment for the further development of treatment methods for obesity in the scientific community
    .

    What kind of method is this? Compared with other weight loss methods, what is special about it? Tripterygium wilfordii is a substance extracted from the roots of a white-flowered plant growing in China.
    This substance has received more and more attention from the scientific community in recent years, because some scientists have confirmed through their experiments that it can prevent And reverse obesity in mice
    .

    For example, a previous study from Harvard University used large-scale drug screening to catch triptorubin by using the common response gene of leptin and endoplasmic reticulum stress to conduct in-depth research on this substance and found this Molecules can not only effectively lose weight in a high proportion, but also have a good corrective effect on metabolic disorders caused by obesity
    .

    A previous study published in the journal Cell on May 21, 2015 provides a new drug target that can be used for in-depth study of triptolide as a weight-loss drug or precursor of weight-loss drugs
    .

    However, because tripterygium can cause hypertension and drowsiness in mice, these scientists want to understand how this compound can treat obesity in the body.
    After understanding its working principle, they can use it.
    These theories have developed a new, safer and more effective weight loss therapy without side effects
    .

    The University of Texas Southwest has gained enlightenment in their experiments and solved this problem to a certain extent
    .

    Their research shows: Tripterygium wilfordii requires a specific protein stored in neurons, and this specific protein affects metabolism
    .

    They also found that they can simulate a "feeding" signal sent to the brains of mice by removing this protein from neurons.
    The result of this is: within two weeks, even if these mice are fed high fat Food, their weight can also be reduced by 7%
    .

    The key to their discovery is that the mice did not seem to suffer so much pain in this experiment compared to previous studies that used triptorubin
    .

    Scientists’ new understanding of how tripterygium works at the cellular level opens up more possibilities for targeted pathways that can improve our metabolic function without causing side effects to our health
    .

    The author of the study, Dr.
    Kevin W.
    Williams, a researcher at the Hypothalamus Research Center at the University of Texas Southwest, explained: “We have not yet discovered all the cell populations that affect weight loss, but our experiments Each new discovery brings us one step closer to the development of more effective and safe obesity treatments
    .

    "They published this research result in an article titled "PERK in POMC neurons connects celastrol with metabolism" in "JCI Insight": Data from the Centers for Disease Control and Prevention in the United States shows that there are more than 30 million diabetic patients in the United States.
    It accounts for nearly 10% of their total population! This new study is expected to improve the glucose metabolism of obese patients such as diabetes, which is indeed good news for those patients! In this new study, scientists are paying attention Focus on a class of cells in the brain called POMC neurons, which are associated with decreased appetite, lower blood sugar levels, and higher energy expenditure when activated
    .

    A study conducted by Dr.
    Williams in 2019 showed : One round of exercise can enhance the activity of POMC neurons for up to two days
    .

    A microscope image from Dr.
    Williams’ laboratory depicts the arcuate nucleus of the hypothalamus: the green cells are POMC neurons, and the red cells express leptin receptors.
    The yellow cells are POMC neurons that express leptin receptors.
    In this latest study, these scientists in the Williams laboratory found that these POMC neurons also play a vital role in promoting weight loss.
    And this effect is exactly similar to the effect of triptorubin in this respect
    .

    After the mice were given this compound, the activity of a protein called PERK in the region of POMC neurons located in their brains decreased; from After removing PERK from these neurons, they can produce as much weight loss as triptorubin, and this does not cause health side effects like anti-obesity drugs
    .

    Dr.
    Williams said: "We found that these mice are thinner.
    But their exercise level is the same as before
    .

    In addition, there are no side effects to interfere with them.
    They do not seem to be lethargic or sick, but we are only preliminary conclusions based on observation.
    We still need in-depth research to clearly understand how this targeted approach will affect Their cardiovascular system and other functions
    .

    "The U.
    S.
    Food and Drug Administration warns people not to use this substance, which is also known as Tripterygium wilfordii in traditional Chinese medicine
    .

    Although the extract of this plant is sold as a supplement, the National Institutes of Health has issued an announcement.
    The warning statement said: Scientists currently do not have enough data to explain its safety and effectiveness
    .

    However, this compound has given scientists important ideas on how to develop new methods of weight loss that are safer and free of side effects in the laboratory.

    .

    For example, in the new study, removal of PERK from POMC neurons, thereby blocking about half of the side effects tripterine in reducing food intake brought about
    .

    Dr.
    Williams is also the University of Texas southwestern Associate Professor of Internal Medicine at the branch campus and a researcher at the Peter O'Donnell Brain Institute, Jr.
    , said: “This shows that in addition to POMC, tripterygium wilfordii can also affect the metabolism of other cell populations.
    We will continue to map these cell types.
    Until we have a more comprehensive understanding of the intricate and intertwined relationships of these pathways
    .

    These theories and new discoveries will definitely help us develop more effective treatments for obesity and diabetes! "Reference material: https://medicalxpress.
    com/news/2021-11-potential-strategy-obesity.
    html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment plans
    .

    If you need health guidance, please go to the formal Visit the hospital
    .

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