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Demyelinating diseases are acquired diseases with different etiologies and clinical manifestations, but with similar characteristics.
The characteristic pathological change is that the myelin sheath of the nerve fiber is lost while the nerve cell remains relatively intact.
In the early stage of multiple MS, a clearer understanding of the microstructure and metabolic abnormalities of normal brain tissue will provide valuable insights into its pathophysiology.
In this cross-sectional study, the researchers recruited 42 individuals who were diagnosed with clinically isolated syndrome (CIS, a single case of central nervous system inflammatory demyelination within 3 months after the first demyelination event) .
diagnosis
MRI post-processing of lesions, NODDI and 23Na MRI
The results showed that compared with the healthy control group, the patients showed higher ODI and total sodium concentrations in normal-appearing white matter including the corpus callosum, while the density of neurons in the corresponding parts was lower.
Compared with the healthy control group, patients showed higher ODI and total sodium concentrations in normal-appearing white matter including the corpus callosum, while the density of neurons in the corresponding parts was lower.
There was no difference in brain volume between patients and controls.
NDI, ODI and TSC of the corpus callosum of the healthy control group (top) and patient (bottom).
NDI, ODI and TSC of the corpus callosum of the healthy control group (top) and patient (bottom).
The connection between the increase of axon dispersion in the corpus callosum and the deterioration of the ability to walk regularly means that the morphological and metabolic changes of this structure may mechanically lead to the occurrence of motor dysfunction and even disability in MS patients.
In summary, the study shows that these two advanced MRI technologies are more sensitive in detecting clinically relevant lesions of early MS, and can predict the condition of MS patients in advance.
references:
Sara Collorone, et al.
oup.
com/brain/advance-article-abstract/doi/10.
1093/brain/awab043/6246099?redirectedFrom=fulltext" target="_blank" rel="noopener">Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event, leave a message here
