Brit J Cancer: Bisphosphonates and Cancer Risk.

It is not clear whether bisphosphonates are associated with cancer risk.
recently published a research paper in British Journal of Cancer, an authoritative journal in the field of oncology, to assess the effects of bisphosphonates on cancer.
researchers retrieved the Pubmed, Embase, Cochrane Library and Web of Science databases from the time each database was established until September 26, 2019.
used random effect models to calculate aggregate effect estimates with 95% CI and explore heterogeneity and publication bias.
the study included 34 articles (4508,261 participants; 403,196 cases).
results showed that bisphosphonate significantly reduced colorectal cancer (RR=0.89,95%CI:0.81-0.98), breast cancer (RR=0.87, 95% CI: 0.82-0.93) and endometrial cancer (RR s 0.75, 95% CI: 0.61-0.94).
but no significant correlation was observed with all cancers.
addition, nitrogen-containing bisphosphonates protect breast cancer (RR=0.94,95%CI:0.90-0.99) and endometrial cancer (RR=0.70,95% CI:0.54-0.92).
non-nitrogen bisphosphonates tend to increase the risk of liver cancer (RR=2.14,95%CI:1.23-3.72) and pancreatic cancer (RR=1.75,95% CI:1.32-2.33).
, bisphosphonates are significantly associated with reducing the risk of colorectal, breast and endometrial cancers, especially nitrogen-containing bisphosphonates.
it should be noted that non-nitrogen bisphosphonates may increase the risk of liver and pancreatic cancer.
large-scale prospective cohort studies are needed to explore the causal relationship between bisphosphonates and cancer risk.
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