Brit J Cancer: Early adult BODY Mass Index and Weight Gain and Breast Cancer Risk
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Last Update: 2020-06-25
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Source: Internet
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Author: User
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In a recent study published in the british journal Journal of Cancer, researchers aimed to test the hypothesis that a 20-year-old body mass index (BMI) alters the relationship between weight gain in adults and breast cancer riskresearchers recruited women (ages 47-73) from the PROCAS (2009-2013) study that predicted cancer risk during screening in Manchester, UKIn 47,042 women, the researchers measured the subjects' baseline and body mass index by age 20 (through recall) and measured changes in weightUsing the Cox model, the researchers estimated the risk ratio (HRs) and 95 percent confidence interval (CIs) for new breast cancer, and explored the relationship between BMI, subsequent weight changes and breast cancer risk at age 20median follow-up time was 5.6 years, with a total of 1142 cases of breast cancer (829 postmenopausal women in the group)In postmenopausal women, the BMI of 20 years of age was negatively correlated with breast cancer (HR was 0.87 per SD (95% CI was 0.79-0.95) and absolute weight gain was negatively correlated with breast cancer (1.23 for every SD change (95% CI is 1.14-1.32)For postmenopausal women with a BMI of 23.4 kg/m2 (75th percentile) of premenopausal population, absolute weight gain is associated with breast cancer risk (1.31 per SD (1.21-1.42) for each Change of SD , but there is no association with a BMI of 23.4 kg/m2 for women with a recalled 20-year-old BMI (interaction P 0.05), it is only in women with a BMI of less than 23.4 kg/m2 at age 20 that weight gain in adulthood increases the risk of breast cancer after menopause
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