Brit J Cancer: Effects of age on outcomes in patients with soraphini to treat hepatocellular carcinoma.

There is no consensus on the effects of soraphine on the efficacy and toxicity of hepatocellular carcinoma (HCC) patients in old age.
patients are often empirically treated at low doses, with the aim of avoiding toxicity while maximizing clinical efficacy.
recently, a study published in British Journal of Cancer, an authoritative journal in the field of oncology, was designed to assess whether age affects total survival (OS) and whether lowering the starting dose affects OS or toxicity in older adults.
In this international multi-center queue study, researchers identified outcomes for patients in the 75- or ≥-75 age group, taking into account common prognostic factors and demographic characteristics in single- and multivariable models.
the study recruited 598 patients, ≥ 792 (14.1%) of the 75-year-olds.
older adults are more likely to develop larger tumors (-gt;7 cm) (39% vs. 33%, p-lt;0.01) and retain liver function (67% vs. 57.7%) (p-lt;0.01).
no ≥ OS for patients aged 75 years and 75 years (7.3 months vs. 7.2 months; HR was 1.00 (95% CI is 0.93-1.08), p=0.97).
between patients aged 75 and ≥75, there was no relationship between the initial dose of Solafeini at 800mg vs. 400mg/200mg and OS.
the overall occurrence of 2-4 sorafeini-related toxicity events in older persons was similar (63.5 vs. 56.7 per cent, p=0.11) compared to older persons aged 75 years.
, however, older people are more likely to deactivation of sorafeini due to toxicity (27.0 vs. 21.6 per cent, p-lt;0.01).
, it can be seen that the clinical outcomes of the elderly are similar to 75-year-old patients and are not related to the dose of solacinie.
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