Brit J Cancer: Microbial markers for predicting colorectal tumor risk

Colorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of cancer death
.

It has been reported that compared with women, men have a higher risk of developing CRC, and women have a 25% lower risk of CRC mortality than men

colorectal cancer

Substantial evidence suggests that dysbiosis of gut microbial communities is associated with colorectal tumors
.

Recently, a research article was published in the British Journal of Cancer, an authoritative journal in the field of oncology.

We conducted a comprehensive literature search of the MEDLINE and EMBASE databases to identify eligible studies
.

We included observational studies exploring associations between microbial biomarkers and colorectal tumors

This meta-analysis included 45 studies to assess the association between microbial markers and colorectal tumors
.

The researchers identified nine fecal microbiota species (namely, Fusobacterium, Enterococcus, Porphyromonas, Salmonella, Pseudomonas, Peptostreptococcus , Actinomyces, Bifidobacterium, and Rosetella spp.

Digestion

Thus, this review provides evidence supporting the association between different types of microbial species and their perspective on their predictive value for colorectal tumors
.

Predictive models developed from case-control studies require further external validation in high-quality prospective studies

This review provides evidence supporting the association between different types of microbial species and their predictive value for colorectal tumors

Original source:

Lili Yu.