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    Home > Active Ingredient News > Antitumor Therapy > Brit J Cancer: Proton pump inhibitors and histamine-2 receptor antagonists and stomach cancer risk

    Brit J Cancer: Proton pump inhibitors and histamine-2 receptor antagonists and stomach cancer risk

    • Last Update: 2020-05-29
    • Source: Internet
    • Author: User
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    Studies have shown that the risk of stomach cancer increases in users of proton pump inhibitors (PPI) and histamine 2 receptor antagonists, and therefore the safety of gastric acid suppression is questionedIn a recent study published in The Journal of Cancer, an authoritative journal of oncology, researchers conducted a case-control study in the Scottish Primary Medical Clinical Informatics Unit (PCCIU) database and a cohort study in the UK biobankin PCCIU, the researchers matched five controls to a case diagnosed between 1999 and 2011 and determined drug use based on GP recordsThe researchers used the conditional Logsitic regression to calculate the ratio ratio (OR) and the 95% confidence interval (CI)In the UK biobank, subjects self-reported when they entered the queue between 2006 and 2010, and the researchers identified the subject's stomach cancer from the Cancer Registry until 2014The researchers used Cox regression to calculate the risk ratio (HR)PCCIU included 1,119 cases and 5,394 controlsThere were 471,779 participants in the UK biobank, which included 250 casesPPI users have a higher risk of stomach cancer in PCCIU and UK biocoffers when using a 1-year lag (corrected OR 1.49, 95% CI is 1.24-1.80; after correction HR is 1.28, 95% CI is 0.86-- 1.90), but these associations are reduced when the 2-year lag is used (corrected OR: 1.13, 95% CI is 0.91-1.40; corrected HR is 1.15, 95% CI is 0.73-1.82)overall, there is little consistent evidence in the study that taking PPI increases the risk of stomach cancer
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