Brit J Cancer: The Relationship between Diabetes and Prostate Cancer Risk

In a recent study published in the journal British Journal of Cancer, the journal of the field of oncology, researchers looked forward to assessing the link between diabetes and prostate cancer risk determined by clinical and molecular characteristicsfrom 1986 to 2014, a total of 49,392 male subjects from the Health Professional Follow-up Study (HPFS) were followedAt baseline, the researchers collected self-reported diabetes data from subjects and updated them every two yearsClinical characteristics of prostate cancer include local, late, fatal, low, moderate and highMolecular features include TMPRSS2:ERG and PTEN subtypesThe researchers used the Cox proportional risk regression model to assess the association between diabetes and the incidence of subtype-specific prostate cancerin a 28-year follow-up, researchers recorded 6,733 cases of prostate cancerCompared to men without diabetes, the overall risk of diabetes (HR 0.82, 95% CI is 0.75-0.90), local (HR 0.82, 95% CI is 0.74-0.92), low-level and moderate prostate cancer (HR 0.77, 95% CI is 0.66-0.90; HR is 0.77,95%.05.05.91)For molecular subtypes, HRs in ERG-negative and ERG-positive cases were 0.63 (0.42-0.95) and 0.72 (0.46-1.12), respectively, and 0.69 (0.48-0.98) and 0.52 (0.19-1.41) for PTEN full cases and PTEN missing cases, respectively, the study is the first to report a link between diabetes and ERG/PTEN prostate cancer, in addition to providing further evidence of a negative link between diabetes and prostate cancer