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This article from the NEJM meta-Journal (NEJM Journal Watch) Brown Fat Might Protect Humans Against Diabetes and Cardiovascular Disease brown fat may help prevent diabetes and cardiovascular disease Author comment: Anthony L.
Komaroff, MD in a large-scale cancer patient population Among them, people with brown fat have a significantly lower risk of diabetes and cardiovascular disease.
Brown fat consumes energy to generate heat, while white fat stores energy.
Studies conducted on mice and other animals have shown that brown fat helps prevent glucose intolerance and vascular disease.
However, although brown fat has been detected in the human body about 10 years ago, it is unclear whether it is beneficial to health.
An international research team analyzed 135,000 positron emission tomography/computed tomography (PET/CT) images of 52,000 cancer patients.
They used propensity score matching to identify people with brown fat and a control group without brown fat.
In patients with brown fat, blood sugar and triglyceride levels are lower, while high-density lipoprotein cholesterol levels are higher.
More importantly, the incidence of type 2 diabetes, dyslipidemia, coronary heart disease, atrial fibrillation/flutter, cerebrovascular disease, congestive heart failure, and hypertension was also significantly reduced in this patient population.
The benefits of brown fat are most obvious in people who are overweight or obese.
Based on this large-scale study, the reviewers came to the following conclusion: Brown fat is associated with a lower prevalence of type 2 diabetes, hypertension, and cardiovascular disease.
However, these results do not clearly tell us whether brown fat independently produces protective effects or is a marker of other causal risk factors.
In addition, these patients receive PET/CT because of cancer, so some people may suggest that the protective effect of brown fat does not exist in people who do not have cancer, but this situation seems unlikely.
Therapeutic interventions aimed at increasing the amount of brown fat are being tested in human subjects.
Commented articles Becher T et al.
Brown adipose tissue is associated with cardiometabolic health.
Nat Med 2021 Jan; 27:58.
(https://doi.
org/10.
1038/s41591-020-1126-7) NEJM journals meta-NEJM journals The NEJM Journal Watch is published by the NEJM Group.
Internationally renowned doctors are invited to comment on important papers in the medical field to help doctors understand and use the latest developments.
"NEJM Frontiers of Medicine" is translated several times a week, published on the app and official website, and selected 2-3 articles are published on WeChat.
Copyright information This article was translated, written or commissioned by the "NEJM Frontiers in Medicine" jointly created by Jiahui Medical Research and Education Group (JMRE) and "New England Journal of Medicine" (NEJM).
The Chinese translation of the full text and the included diagrams are exclusively authorized by the NEJM Group.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn.
Unauthorized translation is an infringement, and the copyright owner reserves the right to pursue legal liabilities.
Komaroff, MD in a large-scale cancer patient population Among them, people with brown fat have a significantly lower risk of diabetes and cardiovascular disease.
Brown fat consumes energy to generate heat, while white fat stores energy.
Studies conducted on mice and other animals have shown that brown fat helps prevent glucose intolerance and vascular disease.
However, although brown fat has been detected in the human body about 10 years ago, it is unclear whether it is beneficial to health.
An international research team analyzed 135,000 positron emission tomography/computed tomography (PET/CT) images of 52,000 cancer patients.
They used propensity score matching to identify people with brown fat and a control group without brown fat.
In patients with brown fat, blood sugar and triglyceride levels are lower, while high-density lipoprotein cholesterol levels are higher.
More importantly, the incidence of type 2 diabetes, dyslipidemia, coronary heart disease, atrial fibrillation/flutter, cerebrovascular disease, congestive heart failure, and hypertension was also significantly reduced in this patient population.
The benefits of brown fat are most obvious in people who are overweight or obese.
Based on this large-scale study, the reviewers came to the following conclusion: Brown fat is associated with a lower prevalence of type 2 diabetes, hypertension, and cardiovascular disease.
However, these results do not clearly tell us whether brown fat independently produces protective effects or is a marker of other causal risk factors.
In addition, these patients receive PET/CT because of cancer, so some people may suggest that the protective effect of brown fat does not exist in people who do not have cancer, but this situation seems unlikely.
Therapeutic interventions aimed at increasing the amount of brown fat are being tested in human subjects.
Commented articles Becher T et al.
Brown adipose tissue is associated with cardiometabolic health.
Nat Med 2021 Jan; 27:58.
(https://doi.
org/10.
1038/s41591-020-1126-7) NEJM journals meta-NEJM journals The NEJM Journal Watch is published by the NEJM Group.
Internationally renowned doctors are invited to comment on important papers in the medical field to help doctors understand and use the latest developments.
"NEJM Frontiers of Medicine" is translated several times a week, published on the app and official website, and selected 2-3 articles are published on WeChat.
Copyright information This article was translated, written or commissioned by the "NEJM Frontiers in Medicine" jointly created by Jiahui Medical Research and Education Group (JMRE) and "New England Journal of Medicine" (NEJM).
The Chinese translation of the full text and the included diagrams are exclusively authorized by the NEJM Group.
If you need to reprint, please leave a message or contact nejmqianyan@nejmqianyan.
cn.
Unauthorized translation is an infringement, and the copyright owner reserves the right to pursue legal liabilities.
