Bulletin on October 29, 2021: The global death toll due to the new crown reached 5 million; the epidemic in many countries around the world rebounded again; this round of epidemic cases exceeded 300 local cases;

As of 7:01 on October 29, 2021, Beijing time, Worldometers real-time statistics show that the total number of confirmed new coronary pneumonia ( COVID-19 ) cases worldwide has exceeded 246.
23 million, with an increase of 463,625 cases, reaching 246,234,007
.

The total number of deaths was 4.

New Coronary Pneumonia COVID-19 Briefing on October 28, 2021: More than 20 provinces have started to administer the new coronavirus vaccine booster; WHO calls for the development of a new generation of new coronavirus vaccine; South Korea announced that it will launch a coexistence strategy with the new crown

Science: Release of vaccines to strengthen protection against primates

Science: Release of vaccines to strengthen protection against primates

The top academic journal "Science" published a research paper on the new coronavirus vaccine, providing new evidence for the vaccine booster to prevent the mutant new coronavirus
.

This preclinical study showed that six months after the macaque was vaccinated with the new crown vaccine mRNA-1273, the third dose of the mRNA vaccine can enhance the animal's antibody response, especially the neutralizing activity of the antibody against the mutant virus

The top academic journal "Science" published a research paper on the new coronavirus vaccine, providing new evidence for the vaccine booster to prevent the mutant new coronavirus

New use of old drug, Masitinib only needs 6 days to reduce the new coronavirus load by 99%

On July 20, 2021, researchers from the University of Chicago and other institutions published a topic in the top international academic journal Science : Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2 (masitinib is a broad Coronavirus 3CL inhibitor can block the replication of SARS-CoV-2)
.

Science

The research team used the strategy of "new use of old drugs".
The research team screened a library of 1900 drugs that have been used safely and found that 20 drugs can effectively inhibit the replication of the new coronavirus in in vitro experiments
.

Among them, masitinib ( masitinib ) is the most effective, which is an oral tyrosine kinase inhibitor that can competitively inhibit the activity of the main protease of the new coronavirus, 3CLpro , thereby inhibiting the replication of the new coronavirus

masitinib 3CLpro

In vivo experiments in mice showed that Masitinib treatment can reduce the titers of the new coronavirus in the lungs and nose of mice to less than 1% of the original, and lung inflammation has also been reduced in just 6 days
.

In addition, Masitinib is equally effective against new crown α, β, and γ mutants in in vitro experiments

Masitinib is also effective against new crown α, β, and γ mutants in in vitro experiments

No entry but no exit, all staff nucleic acid, Beijing Chaoyang District, Tomorrow First City No.

212 people from Shanghai to Beijing South were quarantined in Jinan 14 times

212 people from Shanghai to Beijing South were quarantined in Jinan 14 times

The Office of the Leading Group (Command) of the Jinan Municipal Party Committee for Coordinating Epidemic Prevention and Control and Economic Operation Work announced on the evening of the 28th that a train attendant was judged to be a close contact of a confirmed case of new coronary pneumonia, and there were 212 people on the G14 high-speed train from Shanghai to Beijing South.
Conducted centralized isolation medical observation in Jinan
.

4 new confirmed cases of new coronary pneumonia in Heihe City, Heilongjiang Province

4 new confirmed cases of new coronary pneumonia in Heihe City, Heilongjiang Province

The reporter learned from the press conference on the prevention and control of the new crown pneumonia in Heihe City, Heilongjiang Province that as of 24:00 on October 27, a total of 4 confirmed cases of new crown pneumonia had been reported in Aihui District, Heihe City
.

As of 12:00 on October 28, a total of 658 medical personnel were recruited in the first round of full-staff nuclear testing, and 152,406 were tested.

Inner Mongolia Ordos mobile shelter nucleic acid testing laboratory was put into use

Inner Mongolia Ordos mobile shelter nucleic acid testing laboratory was put into use

Recently, in order to strengthen the detection after nucleic acid sampling, Ordos City, Inner Mongolia, introduced 3 mobile shelter nucleic acid testing laboratories.
At present, 2 have been put in place, 1 is placed in Ordos Disease Control Center, and 1 is placed in Yijin Holo Banner.
The Maternal and Child Health Hospital, after the third unit is in place, is planned to be placed in Dongsheng District
.

The shelter laboratory placed in the Ordos Disease Control Center was put into use on October 28

Merck: If approved by the regulatory authorities, it will quickly deploy anti-coronavirus oral drugs

Merck: If approved by the regulatory authorities, it will quickly deploy anti-coronavirus oral drugs

Merck's CEO Robert Davis said that if the company's anti-coronavirus oral drug monupivir is approved by the regulatory authorities, Merck is ready to produce and distribute tens of millions of doses of monupivir
.

Merck and its partner Ridgeback Biotherapeutics announced on Wednesday that they have entered into a treatment licensing agreement with the United Nations, allowing 105 low- and middle-income countries to share the drug
.

On October 1, Merck announced the mid-term results of its Phase III clinical trial, showing that oral medications can halve the hospitalization rate and mortality rate
.

October 11, Merck to the US Food and Drug Administration Administration ( the FDA ) approved a new crown for emergency oral medication
.

Manage FDA

Pfizer and BioNTech: The US government has purchased more vaccines for children to vaccinate

Pfizer and BioNTech: The US government has purchased more vaccines for children to vaccinate children

Pfizer and BioNTech said in a statement on Thursday that the US government has purchased an additional 50 million doses of Pfizer-BioNTech vaccine to ensure the supply of children
.
All doses will be delivered before April 30, 2022
.

WHO appeals for US$23.
4 billion to implement a new plan to fight the epidemic

WHO appeals for US$23.
4 billion to implement a new plan to fight the epidemic

On October 28, local time, World Health Organization Director-General Tedros Adhanom Ghebreyesus called on the international community to raise US$23.
4 billion in funding for the “Accelerator for Tools Accelerator Fighting New Coronary Pneumonia” program at the WHO's regular press conference on the new crown pneumonia epidemic.
Inequalities in access to the new crown pneumonia vaccine and in the detection and treatment of the new crown virus
.

WHO: The new crown epidemic in Europe has led to an increase in the number of new confirmed cases worldwide

WHO: The new crown epidemic in Europe has led to an increase in the number of new confirmed cases worldwide

World Health Organization Director-General Tedros Adhanom Ghebreyesus said at the WHO's regular press conference on the new crown epidemic on October 28 that since the rate of increase in the epidemic in Europe has exceeded the rate of decline in other regions, the newly reported new crown pneumonia confirmed globally last week The number of cases and the number of new deaths rose for the first time in two months
.

German epidemic continues to rebound, intensive care unit issues warning

German epidemic continues to rebound, intensive care unit issues warning

On October 28, local time, the German epidemic situation continued to rebound.
There were more than 28,000 new infections in a single day , and the 7-day incidence rate per 100,000 people had risen to 130.
2, while the incidence rate was only 85.
6 a week ago
.
The three federal states with the largest number of confirmed cases are Thuringia, Saxony, and Bavaria
.

Infect

Italy's new confirmed cases increase by 43.
2% in a week, and the epidemic rebounds

Italy's new confirmed cases increase by 43.
2% in a week, and the epidemic rebounds

Recently, the Italian independent medical research institutions GIMBE Foundation will release a new crown Wer display, the epidemic mainly from Italy Indices Weekly Update October 20 to 26 had obvious growth
.
After 7 consecutive weeks of decline in new cases, the country’s epidemic has rebounded
.

fund

Only 5 African countries will achieve 40% COVID-19 vaccination target

Only 5 African countries will achieve the 40% COVID- 19 vaccination target Only 5 African countries will achieve the 40% COVID-19 vaccination target

The WHO Regional Office for Africa held an online press conference in Brazzaville, capital of Congo (Brazzaville)
.
According to the content of the press conference, currently only about 77 million people in Africa, that is, 6% of the population have completed the new crown vaccination, and more than 70% of the rich countries have reached the goal of completing the new crown vaccination for more than 40% of the population
.

The WHO Regional Office for Africa held an online press conference in Brazzaville, capital of Congo (Brazzaville)
.
According to the content of the press conference, currently only about 77 million people in Africa, that is, 6% of the population have completed the new crown vaccination, and more than 70% of the rich countries have reached the goal of completing the new crown vaccination for more than 40% of the population
.

The WHO Regional Director for Africa, Morty, said that only 5 African countries, that is, less than 10% of the 54 countries on the African continent, are expected to achieve the goal of covering 40% of the population with the new crown vaccine by the end of the year, unless other countries Can work hard to speed up the vaccination work
.
In order to reach this vaccination goal, African countries need to receive 30 million doses of vaccine every week, which is almost double the current 17 million doses of vaccine received every week
.

The WHO Regional Director for Africa, Morty, said that only 5 African countries, that is, less than 10% of the 54 countries on the African continent, are expected to achieve the goal of covering 40% of the population with the new crown vaccine by the end of the year, unless other countries Can work hard to speed up the vaccination work
.
In order to reach this vaccination goal, African countries need to receive 30 million doses of vaccine every week, which is almost double the current 17 million doses of vaccine received every week
.

Thai Prime Minister Prayut receives new crown vaccine booster

Thai Prime Minister Prayut receives new crown vaccine booster

Thai Prime Minister Prayut received a third dose of the new crown vaccine booster on the 28th local time to prepare for the visit to Glasgow, Scotland at the end of the month to attend the 26th Conference of the Parties of the United Nations Framework Convention on Climate Change (COP26)
.
Prior to this, Prayut received two doses of AstraZeneca's new crown vaccine on March 16 and May 24 this year, and the third booster dose was Pfizer vaccine
.

Singapore found an imported case of new coronavirus AY.
4.
2 strain

Singapore found an imported case of new coronavirus AY.
4.
2 strain

Singapore’s "Lianhe Zaobao" reported on the evening of October 28 local time that the Ministry of Health of Singapore confirmed that an imported case of new coronary pneumonia was found
.
The case was infected with the Delta strain AY.
4.
2, but the virus did not spread to the community
.
AY.
4.
2 is a variant strain of the Delta line
.
The Ministry of Health of Singapore said that although the infectivity of AY.
4.
2 and its ability to cause severe illness are still being studied, it can be considered similar to other Delta strains
.
It is reported that the World Health Organization lists AY.
4.
2 as a variant strain of "note" rather than "note"
.

23 new cases in China

23 new cases in China

From 0-24:00 on October 27, 31 provinces (autonomous regions, municipalities) and the Xinjiang Production and Construction Corps reported 39 new confirmed cases
.
Among them, 16 were imported from abroad (8 in Zhejiang, 3 in Henan, 2 in Fujian, 1 in Beijing, 1 in Hubei, and 1 in Guangxi), including 8 cases that were converted from asymptomatic infections to confirmed cases (all in Zhejiang); local cases 23 cases (eight cases in Gansu Province, Zhangye City in which four cases, Lanzhou 1 Li , Lanzhou New area one case, Jiayuguan City 2 cases; Inner Mongolia seven cases, all in Alxa League; Beijing three cases, all in Changping District; Ningxia 2 cases, both in Yinchuan City; 1 case in Heilongjiang, in Heihe City; 1 case in Shandong, in Rizhao City; 1 case in Sichuan, in Zigong City), including 2 cases converted from asymptomatic infections to confirmed cases (1 case in Beijing, 1 case in Sichuan)
.
There were no new deaths
.
There are no new suspected cases
.

From 0-24:00 on October 27, 31 provinces (autonomous regions, municipalities) and the Xinjiang Production and Construction Corps reported 39 new confirmed cases
.
Among them, 16 were imported from abroad (8 in Zhejiang, 3 in Henan, 2 in Fujian, 1 in Beijing, 1 in Hubei, and 1 in Guangxi), including 8 cases that were converted from asymptomatic infections to confirmed cases (all in Zhejiang); local cases 23 cases (eight cases in Gansu Province, Zhangye City in which four cases, Lanzhou City 1 1 cases of patients , , Lanzhou New Area one case, District of Lanzhou Jiayuguan City, two cases; Inner Mongolia seven cases, all in Alxa League; Beijing three cases are In Changping District; 2 cases in Ningxia, both in Yinchuan City; 1 case in Heilongjiang, in Heihe City; 1 case in Shandong, in Rizhao City; 1 case in Sichuan, in Zigong City), including 2 cases converted from asymptomatic infections to confirmed cases (1 case in Beijing, 1 case in Sichuan)
.
There were no new deaths
.
There are no new suspected cases
.
Jiayuguan City

31 provinces (autonomous regions and municipalities directly under the Central Government) and Xinjiang Production and Construction Corps reported 31 new cases of asymptomatic infections, including 20 imported cases and 11 local cases (4 cases in Shandong, all in Rizhao City; 3 cases in Heilongjiang, all in Heihe City ; 2 cases in Beijing, both in Changping District; 2 cases in Yunnan, both in Dehong Dai and Jingpo Autonomous Prefecture);

31 provinces (autonomous regions and municipalities directly under the Central Government) and Xinjiang Production and Construction Corps reported 31 new cases of asymptomatic infections, including 20 imported cases and 11 local cases (4 cases in Shandong, all in Rizhao City; 3 cases in Heilongjiang, all in Heihe City ; 2 cases in Beijing, both in Changping District; 2 cases in Yunnan, both in Dehong Dai and Jingpo Autonomous Prefecture);

Over 300 local positive cases were newly added in 11 days!

Over 300 local positive cases were newly added in 11 days! Over 300 local positive cases were newly added in 11 days! Over 300 local positive cases were newly added in 11 days!

The current round of the epidemic is fierce
.
Within 11 days, more than 300 new local positive cases were reported nationwide.
The trajectories or gene sequencing of 289 positive infections were directly or indirectly related to Inner Mongolia, Gansu and other places, spreading to 12 provinces, autonomous regions and municipalities
.

The current round of the epidemic is fierce
.
Within 11 days, more than 300 new local positive cases were reported nationwide.
The trajectories or gene sequencing of 289 positive infections were directly or indirectly related to Inner Mongolia, Gansu and other places, spreading to 12 provinces, autonomous regions and municipalities
.
Within 11 days, more than 300 new local positive cases were reported nationwide.
The trajectories or gene sequencing of 289 positive infections were directly or indirectly related to Inner Mongolia, Gansu and other places, spreading to 12 provinces, autonomous regions and municipalities
.

In addition, 17 confirmed cases were reported in Erlianhot City, Inner Mongolia, 8 confirmed cases in Heihe City, Heilongjiang, and 3 cases were initially screened positive.
The source of infection has not yet been found
.

In addition, Erlianhot City, Inner Mongolia, reported 17 confirmed cases, and Heihe City, Heilongjiang, had 8 confirmed cases and 3 initial screening positives.
The source of infection has not been found
.
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