Cai Lintao research group of Shenzhen Advanced Institute of Chinese Academy of Sciences has made new progress in the treatment of tumor with new ultrasonic sensitizer

Recently, Cai Lintao, Shenzhen Institute of advanced technology, Chinese Academy of Sciences, has assembled a series of new metalloporphyrin complexes, and constructed a nano complex acoustic sensitizer by using albumin recombination technology Under the excitation of ultrasound, the precise treatment of acoustic dynamic non-invasive deep tumor has been realized The related paper, metalloporphyrin complex based nanosensitizers for deep tissuetumor therapeutics by nonnvasive sonodynamic therapy, was published in the international famous journal of science and technology small (DOI: 10.1002 / small 201804028) Tumor sonodynamic therapy (SDT) is a strategy to kill tumor by stimulating the acoustic sensitizer to produce cytotoxic reactive oxygen species Ultrasound therapy, which focuses the sound energy on the deep tissue by using the strong penetrating ability of ultrasound, is considered to be a promising non-invasive deep therapy, and the research and development of acoustic sensitizer is the key to the development of sonodynamic therapy Ma Aiqing, Chen Huaqing and Zheng mingbin, members of the research group of CAI Lintao, etc synthesized a series of new complexes with tetramethylphenylporphyrin as ligand and Mn (MN), Zn (Zn), Ti (TI) as metal center, and constructed a high-efficiency nano complex acoustic sensor with human albumin as carrier This kind of acoustic sensitizer still has the characteristics of acoustic energy excitation response in the simulated muscle tissue with a thickness of more than 10 cm After tail vein administration, low-power ultrasound can penetrate the body of tumor bearing mice, which can effectively stimulate the accumulation of sound sensitive agents in the tumor to produce singlet oxygen, thus inhibiting the growth of surface and deep tumors, while not causing damage to normal tissues and organs The results of experiments and theoretical calculation also confirmed that the effect of complexes with different metal centers under the same ultrasonic excitation was quite different, which provided ideas, theoretical and experimental basis for the subsequent research and development of new acoustic sensitizers The project was supported by NSFC, international cooperation of the Ministry of science and technology, research team of NSFC of Guangdong Province, Key Laboratory of nano medicine of Guangdong Province, basic research project of Shenzhen Science and technology innovation Commission and China Postdoctoral Science Foundation.