Camouflage sneaks into human cells New crown virus like a "wolf in sheep's clothing"

Scientists in the United States and Britain have teamed up to create the first model of the new coronavirus prickly protein, revealing how the virus disguises itself and sneaks into human cells without being detected, Physicists. The researchers say the latest discovery provides important information for the development of a new coronavirus vaccine, which is a target for antibody and vaccine research.The surface of the new coronavirus has many raised python proteins, which the virus uses to attach to and enter human cells. Hedgehog proteins are wrapped in polysaccharies, which act like "shields" that can cover viruses and help them evade attacks by the body's immune system.In the study, a team led by Professor Max Crispin of the University of Southampton studied the polysaccharide structure covering the surface of a hedgehog protein simulator and mapped the structure of these polysaccharides.Crisping said: "Wrapping yourself in sugar, the virus is like a wolf in sheep's clothing. But our latest study found that despite the large number of sugar-coated packages, the coronavirus is not as highly shielded as some other viruses.Crispin explains that viruses like HIV, which hover around the host, must constantly evade the immune system, and that they have dense polysaccharid coats as "shields" to respond to immune system attacks; But the low density of polysaccharies also means that the immune system has fewer barriers to using antibodies to the virus, which is encouraging news for vaccine development.Jason McClellan of the University of Texas was also involved in the study. In February, McClellan's team and others reconstructed the 3D structure of the new coronavirus surface prick protein at an atomic scale, with a resolution of 0.35 nanometers, based on a sequence of viral genomes provided by Chinese researchers.The team is currently working with the team that developed the vaccine candidate. For example, a team of professors at the University of Amsterdam in the Netherlands is working to analyze polysaccharine levels on the surface of hedgehog proteins, and researchers say assessing polysaccharine levels on immunogens could help understand the virus's immune response to candidate vaccines. (Science and Technology Daily)