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*For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What protective mechanism does ketogenic diet (KD) use to improve osteoarthritis (OA)? Screenshot of the literature▎Research protocol: This study used anterior cruciate ligament amputation (ACLT) and partial medial meniscectomy to establish a rat knee OA mod.
After 8 weeks of KD or standard diet (SD) treatment, rat knee specimens were taken for testi.
▎Main findings: KD significantly increased the content of β-hydroxybutyric acid (βOHB) in ra.
Compared with SD group, KD significantly reduced the damage caused by OA in articular cartilage and subchondral bo.
Compared with the sham-operated group, the NLRP3 inflammasome and the inflammatory factors interleukin-1β (IL-1β) and interleukin-18 (IL-18) were significantly increased in the SD group, while the levels of these factors were significantly higher in the KD gro.
expression was significantly decreas.
▎Deficiencies and prospects: In conclusion, KD can inhibit the activation of the NLRP3 inflammasome and reduce the inflammatory response of OA, and protect the articular cartilage and subchondral bone of the OA rat mod.
The assistant of the top journals of the clinical literature is online👇 Scan the QR code below the code to jump to the H5 page of "Top Journals' Essentials"Click "Download Now"Open the Doctor Station App and click the columnUse clinical medicine Find the "Top Issues Essentials" follow column and subscribe to the column, and read a new top issue every day! Download the Doctor Station App and subscribe anytime, anywhere~
After 8 weeks of KD or standard diet (SD) treatment, rat knee specimens were taken for testi.
▎Main findings: KD significantly increased the content of β-hydroxybutyric acid (βOHB) in ra.
Compared with SD group, KD significantly reduced the damage caused by OA in articular cartilage and subchondral bo.
Compared with the sham-operated group, the NLRP3 inflammasome and the inflammatory factors interleukin-1β (IL-1β) and interleukin-18 (IL-18) were significantly increased in the SD group, while the levels of these factors were significantly higher in the KD gro.
expression was significantly decreas.
▎Deficiencies and prospects: In conclusion, KD can inhibit the activation of the NLRP3 inflammasome and reduce the inflammatory response of OA, and protect the articular cartilage and subchondral bone of the OA rat mod.
The assistant of the top journals of the clinical literature is online👇 Scan the QR code below the code to jump to the H5 page of "Top Journals' Essentials"Click "Download Now"Open the Doctor Station App and click the columnUse clinical medicine Find the "Top Issues Essentials" follow column and subscribe to the column, and read a new top issue every day! Download the Doctor Station App and subscribe anytime, anywhere~