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*It is only for medical professionals to read.
For reference, MIT Daniel's "Flash Dafa" was first verified by human trials.
Archimedes once said, "Give me a fulcrum, and I can pry the earth!" Now in the field of nerves, there is also a magical study.
Only sound/light with a frequency of 40 Hz may be able to treat Al Zheimer's disease (AD)! What is going on? Let's take a look! What happened to the brain of AD patients? AD is a slow and gradual decline in mental functions including memory, thinking, judgment, and learning ability.
The common manifestation is that the patient gradually becomes more confused and cannot take care of himself.
The older people are, the more likely they are to develop AD.
At present, the cause of AD is not clear, genetic factors may cause the disease, and about 5%-15% of cases are genetically related.
In the brain of AD patients, part of the brain tissue is degenerated, nerve cells are destroyed, and the reactivity of the remaining signal-transmitting chemicals (neurotransmitters) in the brain decreases.
Common brain tissue abnormalities include: β-amyloid deposits, senile plaques, neurofibrillary tangles, and elevated Tau protein levels.
In addition to unresponsiveness, AD patients may also suffer from sleep disorders, decreased brain cell numbers, and cognitive decline.
It is worth noting that because the number of brain cells in AD patients is reduced, their brains usually produce less gamma brain waves (gamma brain waves are mainly produced when focusing, making decisions or remembering).
Figure 1.
The difference between healthy people and AD patients' brain gamma waves.
MIT Daniel takes a different approach: fight AD with sound and light! On the path of AD treatment, scholars are still groping for treatment in the dark.
But her research has become a dawn for the treatment of AD.
She is Cai Lihui, a professor of the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT).
It is precisely because of her in-depth research and outstanding contributions in AD that she became the youngest female academician of the Academia Sinica in one fell swoop.
▌ lLED lights eliminate beta amyloid in the brain of mice.
Previous studies have found that AD patients are often accompanied by symptoms of impaired γ wave oscillation, which is considered to be one of the results of AD.
Many neuroscientists have always believed that gamma waves are used to transmit signals and information.
They never thought that it has the ability to change the physiological state of nerve cells, but Cai Lihui's team did the opposite.
The research team first found Dr.
Edward S.
Boyden, a big cow in the field of MIT optogenetics, who implanted photoreceptors on the nerve cells of mice, and then implanted a light source in the brain of the mice.
After trying the flicker frequency of the light source from 20 times to 80 times per second, it was finally determined to irradiate 40 times per second for one hour.
The results showed that β amyloid in the visual cortex of mice was successfully reduced by 40%-50%, and it also reduced the number of amyloid plaques in the visual cortex of AD mice in the late stage.
Figure 2.
After the mouse brain is implanted with a light source, it can transmit signals at a specific frequency.
Later, the research team verified whether it can use a non-invasive external light source to restore the gamma brain wave frequency? After stimulating the mice with LED lights flashing 40 times per second, they found that the frequency of gamma brain waves in the visual cortex of the mouse brain has also increased! The results of this breakthrough research were published in Nature in 2016 [1]! ▌ 40Hz sound can eliminate AD mice brain β amyloid "no injection, no medicine", only use LED light irradiation to treat AD, many people are skeptical.
And Cai Lihui’s team also responded to these doubts in March 2019: Under the flashing of LED lights with a frequency of 40 Hz, it did clear the beta amyloid and Tau accumulated in the hippocampus and prefrontal cortex of mice.
Protein can also activate the microglia of the brain, enabling them to remove the "harmful substances" from the brain more efficiently.
Next, the research team verified that 40Hz sound stimulation can also reduce beta amyloid in the brains of mice, and the range of action is wider than that of LED lights.
More importantly, when 40Hz dolphin sound and flash therapy are used together, it greatly reduces the number of plaques in the mouse brain and improves the cognitive function of the mice.
The results of this research were published in Cell in 2019 [2].
Figure 3.
After the combined stimulation of light and sound, the left mouse cortex amyloid plaques are reduced.
How effective is the "acousto-light stimulation therapy" in the AD population? Even if the previous research results are more powerful, some people may say, "After all, it is only an experiment conducted on animals, and it is not an effect on humans!" However, the latest news says that "acousto-optic stimulation therapy" has been used in humans.
Has been verified in, what is the effect? Take a look! On March 10 this year, at the 15th International Conference on Alzheimer’s and Parkinson’s Disease, Cognito Therapeutics announced that the company’s innovative digital therapy for the treatment of AD through sound and light stimulation has achieved positive results in phase II clinical trials.
Results: Compared with the control group, after 6 months of treatment, the Alzheimer's Disease Collaborative Study-Activity of Daily Living Scale (ADCS-ADL) score function decline in the treatment group was significantly slowed by 84%, and the performance of the patients in the treatment group The brain atrophy and volume loss associated with AD are significantly reduced by 61%! This is the first digital therapy that can improve memory, cognition, daily functions and reduce brain atrophy in AD patients [3].
This multicenter, randomized controlled clinical trial (OVERTURE Phase II study) evaluated the safety and effectiveness of gamma frequency neuromodulation in the treatment of people with mild to moderate AD.
The study recruited 76 patients with mild to moderate AD over the age of 50 for 6 months of treatment.
During the treatment, the patient received 40 Hz non-invasive audiovisual stimulation at home for one hour every day.
Researchers regularly assessed the patients' cognitive function, changes in biomarkers, and changes in brain volume.
For example, ADCS-ADL is used to measure the cognitive ability of patients; structural magnetic resonance imaging (MRI) is used to assess changes in the patient's brain volume.
The results of the study found that compared with placebo treatment, AD patients who received gamma frequency neuromodulation therapy had significant improvements in memory, cognition, and brain atrophy and volume reduction.
It can be seen that if the results of these studies can be reproducible in larger key trials, then the therapy will be expected to be used in the prevention and treatment of AD patients.
Summary At present, Cai Lihui's team provides a "bright prospect" for the treatment of AD, and may have a huge impact on other diseases involving brain inflammation, and it is even expected to make AD a curable disease in the future.
In short, for a devastating disease like AD that currently has no treatment options, we can only continue to explore and face the difficulties.
I believe that one day, we will usher in the dawn of victory. References: [1] Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, et al.
2016.
Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Nature 540: 230-5 [2] Anthony JM, Abigail LP , Ho-JS et al.
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition[J].
CELL, 2019, 2（177), 256-271.
[3] Cognito Therapeutics Announces Positive Phase 2 Results as First Digital Therapeutic to Improve Memory, Cognition, Functional Abilities and Reduce Brain Atrophy in Alzheimer's Disease Retrieved March 9, 2021.
text starting: the medical profession Neurology channel author: A Ying paper review: Deputy Director Li Tu Ming, MD, editor: Mr.
Lu Li copyright notice If you need to reprint the original article, please contact for authorization-End-Call for papers, welcome to submit to the editor’s mailbox: yxjsjbx@yxj.
org.
cn Please specify: [Submission] Hospital + department + name The manuscript is in the form of a word file, and the remuneration is favorable.
For reference, MIT Daniel's "Flash Dafa" was first verified by human trials.
Archimedes once said, "Give me a fulcrum, and I can pry the earth!" Now in the field of nerves, there is also a magical study.
Only sound/light with a frequency of 40 Hz may be able to treat Al Zheimer's disease (AD)! What is going on? Let's take a look! What happened to the brain of AD patients? AD is a slow and gradual decline in mental functions including memory, thinking, judgment, and learning ability.
The common manifestation is that the patient gradually becomes more confused and cannot take care of himself.
The older people are, the more likely they are to develop AD.
At present, the cause of AD is not clear, genetic factors may cause the disease, and about 5%-15% of cases are genetically related.
In the brain of AD patients, part of the brain tissue is degenerated, nerve cells are destroyed, and the reactivity of the remaining signal-transmitting chemicals (neurotransmitters) in the brain decreases.
Common brain tissue abnormalities include: β-amyloid deposits, senile plaques, neurofibrillary tangles, and elevated Tau protein levels.
In addition to unresponsiveness, AD patients may also suffer from sleep disorders, decreased brain cell numbers, and cognitive decline.
It is worth noting that because the number of brain cells in AD patients is reduced, their brains usually produce less gamma brain waves (gamma brain waves are mainly produced when focusing, making decisions or remembering).
Figure 1.
The difference between healthy people and AD patients' brain gamma waves.
MIT Daniel takes a different approach: fight AD with sound and light! On the path of AD treatment, scholars are still groping for treatment in the dark.
But her research has become a dawn for the treatment of AD.
She is Cai Lihui, a professor of the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT).
It is precisely because of her in-depth research and outstanding contributions in AD that she became the youngest female academician of the Academia Sinica in one fell swoop.
▌ lLED lights eliminate beta amyloid in the brain of mice.
Previous studies have found that AD patients are often accompanied by symptoms of impaired γ wave oscillation, which is considered to be one of the results of AD.
Many neuroscientists have always believed that gamma waves are used to transmit signals and information.
They never thought that it has the ability to change the physiological state of nerve cells, but Cai Lihui's team did the opposite.
The research team first found Dr.
Edward S.
Boyden, a big cow in the field of MIT optogenetics, who implanted photoreceptors on the nerve cells of mice, and then implanted a light source in the brain of the mice.
After trying the flicker frequency of the light source from 20 times to 80 times per second, it was finally determined to irradiate 40 times per second for one hour.
The results showed that β amyloid in the visual cortex of mice was successfully reduced by 40%-50%, and it also reduced the number of amyloid plaques in the visual cortex of AD mice in the late stage.
Figure 2.
After the mouse brain is implanted with a light source, it can transmit signals at a specific frequency.
Later, the research team verified whether it can use a non-invasive external light source to restore the gamma brain wave frequency? After stimulating the mice with LED lights flashing 40 times per second, they found that the frequency of gamma brain waves in the visual cortex of the mouse brain has also increased! The results of this breakthrough research were published in Nature in 2016 [1]! ▌ 40Hz sound can eliminate AD mice brain β amyloid "no injection, no medicine", only use LED light irradiation to treat AD, many people are skeptical.
And Cai Lihui’s team also responded to these doubts in March 2019: Under the flashing of LED lights with a frequency of 40 Hz, it did clear the beta amyloid and Tau accumulated in the hippocampus and prefrontal cortex of mice.
Protein can also activate the microglia of the brain, enabling them to remove the "harmful substances" from the brain more efficiently.
Next, the research team verified that 40Hz sound stimulation can also reduce beta amyloid in the brains of mice, and the range of action is wider than that of LED lights.
More importantly, when 40Hz dolphin sound and flash therapy are used together, it greatly reduces the number of plaques in the mouse brain and improves the cognitive function of the mice.
The results of this research were published in Cell in 2019 [2].
Figure 3.
After the combined stimulation of light and sound, the left mouse cortex amyloid plaques are reduced.
How effective is the "acousto-light stimulation therapy" in the AD population? Even if the previous research results are more powerful, some people may say, "After all, it is only an experiment conducted on animals, and it is not an effect on humans!" However, the latest news says that "acousto-optic stimulation therapy" has been used in humans.
Has been verified in, what is the effect? Take a look! On March 10 this year, at the 15th International Conference on Alzheimer’s and Parkinson’s Disease, Cognito Therapeutics announced that the company’s innovative digital therapy for the treatment of AD through sound and light stimulation has achieved positive results in phase II clinical trials.
Results: Compared with the control group, after 6 months of treatment, the Alzheimer's Disease Collaborative Study-Activity of Daily Living Scale (ADCS-ADL) score function decline in the treatment group was significantly slowed by 84%, and the performance of the patients in the treatment group The brain atrophy and volume loss associated with AD are significantly reduced by 61%! This is the first digital therapy that can improve memory, cognition, daily functions and reduce brain atrophy in AD patients [3].
This multicenter, randomized controlled clinical trial (OVERTURE Phase II study) evaluated the safety and effectiveness of gamma frequency neuromodulation in the treatment of people with mild to moderate AD.
The study recruited 76 patients with mild to moderate AD over the age of 50 for 6 months of treatment.
During the treatment, the patient received 40 Hz non-invasive audiovisual stimulation at home for one hour every day.
Researchers regularly assessed the patients' cognitive function, changes in biomarkers, and changes in brain volume.
For example, ADCS-ADL is used to measure the cognitive ability of patients; structural magnetic resonance imaging (MRI) is used to assess changes in the patient's brain volume.
The results of the study found that compared with placebo treatment, AD patients who received gamma frequency neuromodulation therapy had significant improvements in memory, cognition, and brain atrophy and volume reduction.
It can be seen that if the results of these studies can be reproducible in larger key trials, then the therapy will be expected to be used in the prevention and treatment of AD patients.
Summary At present, Cai Lihui's team provides a "bright prospect" for the treatment of AD, and may have a huge impact on other diseases involving brain inflammation, and it is even expected to make AD a curable disease in the future.
In short, for a devastating disease like AD that currently has no treatment options, we can only continue to explore and face the difficulties.
I believe that one day, we will usher in the dawn of victory. References: [1] Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, et al.
2016.
Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Nature 540: 230-5 [2] Anthony JM, Abigail LP , Ho-JS et al.
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition[J].
CELL, 2019, 2（177), 256-271.
[3] Cognito Therapeutics Announces Positive Phase 2 Results as First Digital Therapeutic to Improve Memory, Cognition, Functional Abilities and Reduce Brain Atrophy in Alzheimer's Disease Retrieved March 9, 2021.
text starting: the medical profession Neurology channel author: A Ying paper review: Deputy Director Li Tu Ming, MD, editor: Mr.
Lu Li copyright notice If you need to reprint the original article, please contact for authorization-End-Call for papers, welcome to submit to the editor’s mailbox: yxjsjbx@yxj.
org.
cn Please specify: [Submission] Hospital + department + name The manuscript is in the form of a word file, and the remuneration is favorable.
