Can drugs really bring people back to old age?

Aging Cell, a leading journal in biology, recently published a research paper entitled "Reversal of epigenetic aging and immunosenescent in humans" (reversing the trend of epigenetic aging and immunoage) that revealed that humans can slow aging by taking certain drugs, shocking the academic community!images from cellAge
reported that a small clinical study conducted in California by researchers at THE University of California, Stanford and UBC has shown for the first time that the epigenetic clock used in the body to indicate a physiological age can be reversedPhysiological age, also known as "biological age", is a medical, biological measure of age, it reflects the degree of growth, maturation or aging, is the age of a person's physical conditionGenerally speaking, the physiological age increases with the actual age, but due to various effects, the physiological age may be much smaller or probably much larger than the actual ageWhat is the god drug thatreverse age?this amazing study does this? The researchers asked 10 healthy male volunteers to take three commonly used drugs: growth hormone, dehydrohydrocytesandone and metformin, and after a year of follow-up, they tested the s markers on their human genome and found that their physiological age was reversed by 2.5 years, and that their immune systems showed signs of rejuvenate, and many age-related diseases showed a reduced risk indexwere surprised by the surprise, the study's participants, who had just wanted to slow down the epigenetic clock, but did not expect it to turn the clock aroundThe breakthrough study, published in the September issue of the journal Aging Cell, was also reported in the journal Naturethymus regeneration - the cause of reverse growth?this clinical trial is primarily aimed at testing whether growth hormone can be safely used in humans to restore the function of thymus tissueThe thymus is located between the lungs and the sternum and is essential for immune functionWhite blood cells are produced in the bone marrow and then mature dedicureins in the thymus, where they grow into specific T-cells that help the body fight infection and cancerHowever, after puberty the thymus begins to atrophy and is gradually filled with fatevidence from animal and some human clinical trials that growth hormone stimulates the regeneration of the thymusBut growth hormone can also promote the development of diabetesAs a result, the researchers combined growth hormone with two widely used antidiabetic drugs, Dehydrometrexande (DHEA) and metformin, as a cocktail therapyAfter receiving FDA approval, immunologist Gregory Fahy led a clinical trial aimed at thymus regeneration, immunoreconstruction and reducing insulin resistancein this clinical trial, researchers took blood samples from participants during treatmentTests showed that each participant's blood cell count was rejuvenatedThe researchers also used magnetic resonance imaging (MRI) to determine the composition of the thymus at the beginning and end of the studyIt was found that the fat accumulated in the thymus of seven participants had been replaced by regenerative thymus tissuethymus is vital to the body's immune system, the thymus is an important lymphatic organ, but also the body's early aging organsThe depletion of immune cell populations caused by thymus aging has long been known to further lead to the collapse of the T-cell receptor pool, triggering a range of age-related immune diseases and cancersstudies have found that the immune function of the thymus-based is often seen in centenarians, which also suggests a link between healthy thymus and longevityFigure 1The increase in thymus volumeresults are significant, but cannot be directly promoted
although it has been added to the journal Nature, but this study still has a lot to questionFirst, the paper does not explicitly explain this mechanism for reversing agingMoreover, the number of clinical studies was small (one group of 7 and 3 in the other) and only two blood collections were carried out during treatment (one year), so the reliability of the test results needed further proofin addition , the volunteers also experienced minor side effects that may be associated with treatment, including joint pain (2 cases), anxiety disorder (1 case), carpal tunnel syndrome (1 case), fluid retention (1 case), mild male breast development (1 case) and muscle aches (1 case) But we must acknowledge that, as the conclusion of this paper, the specific combination of growth hormone, DHEA and metformin does provide us with new ways to truly reverse aging, and similar treatments may be inspired by this." Let's wait and see! References: fahy GM, Brooke RT, Watson JP, et al Reversal of epigenetic aging and adesenescent trend in humans Aging Cell 2019;e13028 DOI: 10.1111/acel.13028