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Non-alcoholic fatty liver (NAFLD, commonly known as fatty liver) is the most common chronic liver disease, affecting approximately 25% of adults
.
NAFLD is driven by metabolic syndrome and is associated with obesity, insulin resistance, and hyperlipidemia
.
NAFLD includes non-alcoholic fatty liver (NAFL), as well as non-alcoholic steatohepatitis (NASH), fatty liver fibrosis, liver cirrhosis and so on
.
Source: gastro Due to its high prevalence, non-alcoholic fatty liver is now the fastest growing cause of liver-related mortality in the world, and has become an important cause of end-stage liver disease, primary liver cancer and liver transplantation
.
A study published last year in the leading gastrointestinal journal GUT showed that even mild fatty liver can increase the risk of death by 71%, and the risk is proportional to the severity of fatty liver
.
At present, there are no clinically approved drugs for the treatment of NAFLD, and only life>
.
But as we all know, it is difficult to lose weight or exercise by personal will
.
A study published in Hepatology found that although weight loss can improve fatty liver, more than half of people fail to achieve their target weight
.
Another study showed that if life>
.
But this is more difficult and expensive
.
Because it is difficult to cure NAFLD by one's own will, it is accompanied by serious effects and consequences with you and me, so new therapies are urgently needed to treat it
.
Recently, a study published in the MED magazine issued by Cell Press found a potential new treatment for fatty liver.
The results of the study showed that leptin injection can reduce liver fat in patients with fatty liver after 12 months, and The NASH score decreased significantly
.
Source: DOI: https://doi.
org/10.
1016/j.
medj.
2021.
04.
001 What is leptin? Leptin is a protein hormone that is closely related to appetite control and hunger satisfaction
.
It was named in 1995 by scientists such as Maffei from Rockefeller University in the United States [2].
It is derived from the Greek word "lepto", which means "thin"
.
In our body, leptin is mainly secreted by adipose tissue, and then stimulates the receptors in the hypothalamus, prompting the body to reduce food intake, increase energy release, inhibit the synthesis of fat cells, and then reduce weight
.
In this study on MED, the researchers selected 9 male patients with NASH and relatively low leptin levels (less than 9 ng/ml, with an average BMI of 28.
2 ± 1.
6 kg/m2) and 23 simultaneous Patients with partial steatosis and NASH
.
Both groups of patients received leptin therapy for a period of one year
.
Participants received subcutaneous injections of leptin every day, the treatment dose was 0.
1 mg/kg/day, and the maximum dose was 10 mg/day
.
The main result is the NASH score, and the secondary results are liver fat percentage, body weight and body fat
.
The results of the study found that for fatty liver participants with low leptin levels, after 12 months of leptin treatment, their weight lost 4.
5% ± 3.
9%, and most of the loss was fat
.
At the same time, the patient's insulin sensitivity and blood sugar levels have also improved
.
Subject characteristics at baseline and 12 months after leptin treatment The researcher further measured by magnetic resonance imaging (MRI) and found that after 12 months of leptin treatment, the patient’s liver fat content decreased significantly, and the average level of liver fat From 19% ± 8% at baseline to 13% ± 9% after 12 months; NASH score ranges from 8 ± 3 to 5 ± 2 at baseline
.
Of the 7 subjects who completed 12 months of treatment, 5 had a total score reduction of at least 3 points for NASH
.
(C) Changes in liver fat percentage over time (D) Individual NASH scores at baseline and 12 months.
Unfortunately, in this study, the author pointed out that this leptin treatment will only cause early overweight and leptin Patients with low levels of fatty liver benefit.
When the patient is determined to be obese, there is almost no benefit to injecting leptin
.
(The BMI threshold standards for overweight and obesity set by the World Health Organization (WHO) are 25 and 30 kg/m2) Source: Why is CDC injection of leptin useless for obese patients? First of all, we need to understand the mechanism of leptin.
Leptin acts as an afferent signal in the negative feedback loop, and it mainly acts on hypothalamic neurons
.
At present, the feedback regulation loop of leptin has been identified with the following three steps: (1) Leptin monitors the size of adipose tissue and sends signals to the hypothalamus; (2) The center of the hypothalamus receives and Integrate the strength of leptin signal; (3) The effect system (including the sympathetic nervous system) regulates some information substances to control the body's energy intake and energy expenditure
.
In obese patients, the level of leptin rises due to the increase in body fat
.
If the leptin level in the body rises by a large amount, it will produce long-term high-intensity stimulation to the leptin receptor, which will reduce the sensitivity of the leptin receptor to leptin, and form a leptin body resistance (similar to the type 2 diabetes Insulin resistance)
.
Previous studies have also found that lean wild-type animals have lower levels of leptin and weight loss after leptin treatment.
In the obese mouse model induced by high-fat diet, injection of leptin did not produce significant weight loss
.
Is the fat liver patient with obesity and leptin resistance hopeless? The answer is: yes! Since the method of increasing leptin does not work, we can start with increasing the sensitivity of leptin receptors
.
We can reverse the disorder in the leptin signaling pathway through the following life>
.
Studies have shown that a weight loss of 10% or more can improve NASH in 90% of patients
.
Fatty liver patients with obesity and leptin resistance should eat more protein
.
Enough protein can improve the sensitivity of leptin, as long as a little leptin can burn a lot of fat
.
Fatty liver patients with obesity and leptin resistance ensure adequate sleep
.
Sleep is very important to improve the sensitivity of leptin receptors, not only for beauty, but also for weight loss
.
Author | Jessica Editor | Jessica View the latest journal information, submission experience, click to read the original text
.
NAFLD is driven by metabolic syndrome and is associated with obesity, insulin resistance, and hyperlipidemia
.
NAFLD includes non-alcoholic fatty liver (NAFL), as well as non-alcoholic steatohepatitis (NASH), fatty liver fibrosis, liver cirrhosis and so on
.
Source: gastro Due to its high prevalence, non-alcoholic fatty liver is now the fastest growing cause of liver-related mortality in the world, and has become an important cause of end-stage liver disease, primary liver cancer and liver transplantation
.
A study published last year in the leading gastrointestinal journal GUT showed that even mild fatty liver can increase the risk of death by 71%, and the risk is proportional to the severity of fatty liver
.
At present, there are no clinically approved drugs for the treatment of NAFLD, and only life>
.
But as we all know, it is difficult to lose weight or exercise by personal will
.
A study published in Hepatology found that although weight loss can improve fatty liver, more than half of people fail to achieve their target weight
.
Another study showed that if life>
.
But this is more difficult and expensive
.
Because it is difficult to cure NAFLD by one's own will, it is accompanied by serious effects and consequences with you and me, so new therapies are urgently needed to treat it
.
Recently, a study published in the MED magazine issued by Cell Press found a potential new treatment for fatty liver.
The results of the study showed that leptin injection can reduce liver fat in patients with fatty liver after 12 months, and The NASH score decreased significantly
.
Source: DOI: https://doi.
org/10.
1016/j.
medj.
2021.
04.
001 What is leptin? Leptin is a protein hormone that is closely related to appetite control and hunger satisfaction
.
It was named in 1995 by scientists such as Maffei from Rockefeller University in the United States [2].
It is derived from the Greek word "lepto", which means "thin"
.
In our body, leptin is mainly secreted by adipose tissue, and then stimulates the receptors in the hypothalamus, prompting the body to reduce food intake, increase energy release, inhibit the synthesis of fat cells, and then reduce weight
.
In this study on MED, the researchers selected 9 male patients with NASH and relatively low leptin levels (less than 9 ng/ml, with an average BMI of 28.
2 ± 1.
6 kg/m2) and 23 simultaneous Patients with partial steatosis and NASH
.
Both groups of patients received leptin therapy for a period of one year
.
Participants received subcutaneous injections of leptin every day, the treatment dose was 0.
1 mg/kg/day, and the maximum dose was 10 mg/day
.
The main result is the NASH score, and the secondary results are liver fat percentage, body weight and body fat
.
The results of the study found that for fatty liver participants with low leptin levels, after 12 months of leptin treatment, their weight lost 4.
5% ± 3.
9%, and most of the loss was fat
.
At the same time, the patient's insulin sensitivity and blood sugar levels have also improved
.
Subject characteristics at baseline and 12 months after leptin treatment The researcher further measured by magnetic resonance imaging (MRI) and found that after 12 months of leptin treatment, the patient’s liver fat content decreased significantly, and the average level of liver fat From 19% ± 8% at baseline to 13% ± 9% after 12 months; NASH score ranges from 8 ± 3 to 5 ± 2 at baseline
.
Of the 7 subjects who completed 12 months of treatment, 5 had a total score reduction of at least 3 points for NASH
.
(C) Changes in liver fat percentage over time (D) Individual NASH scores at baseline and 12 months.
Unfortunately, in this study, the author pointed out that this leptin treatment will only cause early overweight and leptin Patients with low levels of fatty liver benefit.
When the patient is determined to be obese, there is almost no benefit to injecting leptin
.
(The BMI threshold standards for overweight and obesity set by the World Health Organization (WHO) are 25 and 30 kg/m2) Source: Why is CDC injection of leptin useless for obese patients? First of all, we need to understand the mechanism of leptin.
Leptin acts as an afferent signal in the negative feedback loop, and it mainly acts on hypothalamic neurons
.
At present, the feedback regulation loop of leptin has been identified with the following three steps: (1) Leptin monitors the size of adipose tissue and sends signals to the hypothalamus; (2) The center of the hypothalamus receives and Integrate the strength of leptin signal; (3) The effect system (including the sympathetic nervous system) regulates some information substances to control the body's energy intake and energy expenditure
.
In obese patients, the level of leptin rises due to the increase in body fat
.
If the leptin level in the body rises by a large amount, it will produce long-term high-intensity stimulation to the leptin receptor, which will reduce the sensitivity of the leptin receptor to leptin, and form a leptin body resistance (similar to the type 2 diabetes Insulin resistance)
.
Previous studies have also found that lean wild-type animals have lower levels of leptin and weight loss after leptin treatment.
In the obese mouse model induced by high-fat diet, injection of leptin did not produce significant weight loss
.
Is the fat liver patient with obesity and leptin resistance hopeless? The answer is: yes! Since the method of increasing leptin does not work, we can start with increasing the sensitivity of leptin receptors
.
We can reverse the disorder in the leptin signaling pathway through the following life>
.
Studies have shown that a weight loss of 10% or more can improve NASH in 90% of patients
.
Fatty liver patients with obesity and leptin resistance should eat more protein
.
Enough protein can improve the sensitivity of leptin, as long as a little leptin can burn a lot of fat
.
Fatty liver patients with obesity and leptin resistance ensure adequate sleep
.
Sleep is very important to improve the sensitivity of leptin receptors, not only for beauty, but also for weight loss
.
Author | Jessica Editor | Jessica View the latest journal information, submission experience, click to read the original text
