Can statins reduce Parkinson's risk?

*For medical professionals to read and reference clinical information, the burden of 1s exposure to cerebrovascular disease pathology is associated with progressive Parkinsonism in the elderly, but it is unclear whether the use of statins can reduce the risk of Parkinsonism in the elderly risk
.

Research from Neurology shows that statin use is effective in reducing the risk of Parkinson's disease in adults
.

The study conducted an annual clinical trial of four Parkinson's signs in older adults (n = 2841) and assessed statin use based on findings across all medications
.

If there is clinical evidence of two or more Parkinsonian signs, Parkinsonism is present
.

Post-brain death examinations collected some pathological indicators of atherosclerosis including the great vessels in the circle of Willis
.

The study examined whether baseline statin use was associated with Parkinson's disease events
.

Then in the deceased, it was examined whether statin use before death was associated with pathology and whether pathology linked statin use to Parkinson's disease
.

The results of the study are as follows: (1) During an average follow-up period of 6 years, 50% of the subjects developed Parkinson's syndrome
.

(2) Baseline statin use (n=936) was associated with lower risk controlling for demographics, vascular risk factors and disease (HR=0.
84, 95%CI: 0.
74-0.
96, p=0.
008)
.

(3) Among patients who died (n=1044, age at death [mean=89.
2, SD=6.
7]), the use of statins before death was associated with a lower odds of atherosclerosis (OR=0.
63, 95%CI: 0.
50) -0.
79, p < 0.
001)
.

(4) In the intermediate analysis, the direct (OR=0.
73, 95%CI: 0.
54-0.
93, p=0.
008) and indirect (OR=0.
92, 95%CI: 0.
88-0.
97) and indirect (OR=0.
92, 95%CI: 0.
88-0.
97) p=0.
002) pathway linked statins to Parkinson's, suggesting that atherosclerosis mediated 17% of the association between statins and Parkinson's
.

Taken together, adults using statins have a lower risk of Parkinson's disease, which may be mediated in part by lower odds of cerebral atherosclerosis
.

These findings underscore the role of cerebrovascular disease in later-life Parkinsonism and suggest a potential role for statins in reducing its extent
.

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Subscribe to the disciplines you care about The subject is pushed every day, and a new top issue is read every day! Such a useful tool, let's use it! References: [1] Oveisgharan S, Yu L, Barnes LL, Agrawal S, Schneider JA, Bennett DA, Buchman AS.
Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.
Neurology.
2022 Mar 23:10.
1212/WNL.
0000000000200182.
doi:10.
1212/WNL.
0000000000200182.
Epub ahead of print.
PMID:35321928.