Can the new coronavirus kill tumor cells, and this wave of "God's operation" can be replicated?

a malignant lymphoma patient infected with the new coronavirus, the tumor in the body disappeared without hormone therapy, chemotherapy, immunotherapy. The body's immune system often treats tumor cells as normal cells, at which point the patient's immune system becomes a "sleeping lion". Experts believe that the invasion of the new coronavirus may have awakened the "sleeping lion", stimulating the body's specific immunity or broad-spectrum immunity, so as to kill tumor cells and other viruses.
, a three-paragraph case report published in the British Journal of Hematology shocked the world when a
patient with malignant lymphoma contracted the new coronavirus, and the tumours in the body disappeared largely without hormone therapy, chemotherapy and immunotherapy.
in marveling at this wave of "God's operation", more questions followed: Is the new coronavirus repelling tumor cells? Is there a possible universal value in this case? Can cancer patients have a new path to cure? On January 11th, a reporter from Science and Technology Daily took these questions to interview several scholars in the field of immunization.In the paper, the authors from the Department of Hematology at the Royal Hospital of Cornwall in the UK speculate that there may be two reasons why the tumour magically disappears after contracting the new coronavirus: the response of pathogen-specific T-cells to tumor antigens, and the activation of inflammatory cytokines on natural killer cells. That is, the new coronavirus may activate the body's own immune function from both specific and broad-spectrum immunity.
tumor cells grow and metasign uncontrolled because the body's immune system treats them as normal cells, when the cancer patient's immune system becomes a "sleeping lion." The invasion of the new coronavirus is equivalent to waking up the "sleeping lion" and drying out tumor cells and other viruses.
different scholars hold different views on the specific mechanism of occurrence of this phenomenon, which scientists are most concerned about.
told Science and Technology Daily that the case may have been a coincidence. Coincidental points are likely to be related to "small peptides". Small segments of peptides on the shell of the new coronavirus protein, or small segments of peptides released after cell infection, can be identified if they are similar to antigens on the surface of tumor cells, which excite the lethal T cells produced by the obtained immunity. This means that T-cells recognize tumor cells through the "introduction" of the new coronavirus, which specificates the destruction of tumor tissue.
process is specific to immunity in the human body.
"but it's just speculation, it all depends on further analysis by the research team." The scholar said, but from the performance of patients with neo-corona pneumonia, this inference is very likely, because the occurrence of "inflammatory cytokine storm" in severe patients is the main cause of death, which means that the new coronavirus will induce the body's immune system "crazy" release of inflammatory factors, resulting in great lethality, so as long as "recognized", it is entirely possible to kill the patient's malignant tumor within 4 months.
the current situation, I personally judge that the new coronavirus activates broad-spectrum immunity in this patient." Yang Guanghua, a
professor at Shanghai Ocean University and founder of Bean Bio, told Science and Technology Daily that the paper mentions a significant reduction in the number of tumor cells and EB viruses previously infected by patients, so it is likely that the new coronavirus activates the patient's overall immune system, causing a sharp increase in the number of immune cells, including natural killer cells, and all cells or molecules identified as "heterogeneity".
" current simple report reveals less information, is difficult to make a comprehensive judgment, and does not rule out the possibility of specific immunity. Yang Guanghua said.
fact, in addition to activating the immune system, viruses have precedents for killing tumor cells directly, known as lysolytic viruses. The U.S. Food and Drug Administration (FDA) has approved a genetically engineered lysomavirus to treat advanced melanoma, according to public information. At least three lysovirus therapies have been approved worldwide.
is it possible that the new coronavirus is directly "dissolved"? Yang Guanghua responded: "It is difficult to reach this conclusion at this time, it is necessary to confirm that the patient's tumor cell surface receptors to accept the new coronavirus into the line." However, from the genome analysis of the new coronavirus, should not have the characteristics of solute tumor. Theis more important for cancer patients than the treatment and the rationale. Can cancer patients actively infected with the new coronavirus also be able to drive out the tumor?
high-risk operation, do not imitate!
have made this appeal in response to possible irrationality. Many professionals have also expressed concern because of the chaos of veterinary drugs to treat cancer and malaria parasites to cure cancer in previous cancer circles.
it is difficult to determine whether this case can be repeated in others until further research is unsuccessful. Even if the relevant mechanisms in the future are clear and proved repeatable, modern methods of diagnosis and treatment will certainly be optimized.
, the operation of directly infecting the new coronavirus is too primitive! Contrary to the basic requirements of safety and effectiveity.
now that the paper reports on the "dawn" of tumor subside, how will scientists take advantage of this possible effect of the new coronavirus?
Yang Guanghua said that tumor vaccines can be made, tumor markers can be found, genetic modification can be carried out . . .
If specific immunity is activated and the associated immune pathways have been formed, the quickest way to find small-segment peptides that stimulate immunity is to synthesize recombinant proteins through genetic engineering for the treatment of related types of tumors. The type of tumor is also evaluated during treatment to see if it matches this specific immunity.
if it is broad-spectrum immunity, the new coronavirus can also be modified to remove the toxic part, forming a viral tumor vaccine vector. "Transforming the virus to form tumor vaccines and use them as vectors is a good way to form more efficient and highly imitative immunity than existing RNA and DNA vaccines." But there is still a long way to go, Yang said, and because the new coronavirus spreads through the respiratory system, it is difficult to control its spread, so it may be longer.
And if it is a third cause, caused by a new coronavirus lysoma, then the new coronavirus still needs to be modified so that it only attacks tumor cells, but is harmless to normal cells, and forms a systematic therapy.
In addition, in terms of possible universality, since the patient is classic Hodgkin's lymphoma, which is different from other solid tumors, so the universality is relatively low, if the new coronavirus is to activate the overall immune system leading to tumor death, then it will be more likely to find other similar cases to improve universality, and if the activation of specific immunity, then universality may not be great. case shocked the world because, in addition to the incredible results presented by medical images, it provided a clue and possibility for cancer treatment.
similar cases have precedents in the field of treatment
, such as the emergence of "Berlin Patients", which allows scholars to "unlock" knowledge points in basic research that the absence of the CCR5 gene can protect against
.
case is the "meeting point" of the huge human genome, transcriptions, proteomics, life activities of cancer cells, transcriptional translation of new coronavirus, etc.
the interactions that may be involved in them are complex and need further study.
"to understand what has changed in the whole system, and how the tumor cells themselves, the tumor micro-environment, and how it works, really need to do a very in-depth analysis of this case." Yang Guanghua said.
team of Chinese scientists can't wait for someone else's findings.
"s case happened to have a PET-CT test to find the tumor gone, but it is possible that many similar cases have not been detected. Yang Guanghua said, "The cases of cancer patients infected with the new coronavirus at the same time should also be in our country." The
opened "a door" for qualified research groups in China.
" before a lot of patients are treated, the relevant departments have contact information, I think it is possible to open the relevant research, such as statistics on whether there are cancer patients, contact to see his current condition, or give him another check." If a patient's tumor is found to have shrunk or disappeared, it can be immediately included in the analysis. Yang Guanghua said.