Can this substance in the blood of young mice really make old mice "rejuvenate"?
Last Update: 2020-06-19
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Although wishes are beautiful, we must admit that we don't know much about agingIn order to find a way to prolong life, scientists have done a series of experimentsOne of the most frightening sounds is that the blood of young mice can make old mice "glow with youth"< br / > ▲ the secret of "rejuvenated children" may be hidden in the blood (source: pixabay) < br / > it can be imagined that the research has been controversial since it was published, and some scientists claim that its results cannot be repeatedBut other scientists are curious, is this because the blood composition is too complex, the level of the real effective anti-aging substances fluctuates, so that the results can not be repeated? < br / > Professor Shin Ichiro Imai from the school of medicine at Washington University has been interested in this issue for a long timeHis team believes that the simple blood transfusion method is too rough, and only by finding the molecules that really work can we find the secret of anti-aging accurately< br / > in a study published online this week in cell metabolism, his team found that a magic molecule called enampt might be an "anti-aging factor" in the blood of young mice< br / > in terms of function, Nampt is an important enzyme in mammalian body, which is involved in the biosynthesis of NAD +, and the latter is a star in the field of anti-aging in recent yearsMany studies have shown that with aging, the level of NAD + in animals will decrease systematically, which will lead to a series of pathological changes related to aging< br / > the enampt found in this study has one more e in front of this important enzyme moleculeIt means extracellularThat is to say, enampt can travel all over the body with the blood to assist in the synthesis of NAD +< br / > as they expected, there was a significant decrease in the level of enampt in older mice and humansOverexpression of enampt can also maintain the biosynthesis of NAD + in the aging process of mice< br / >In addition, their blood glucose regulation, photosensitive function and cognitive function were significantly improvedThe researchers also found that the median life span of genetically modified female mice was significantly longer This phenomenon was not observed in genetically modified male mice < br / > to better understand the role of enampt, the researchers isolated and purified the protein from the blood of 4-12 month old young or middle-aged mice, and infused it into the body of 26 month old female mice Amazingly, mice receiving enampt had a median life expectancy 10% higher than the control group, and looked healthier physically! < br / > Professor Imai, who led the study, said: "they are just ordinary old mice without special genetic modification But when they were given enampt, their motor behavior, sleep quality, and physical appearance became very similar to that of young mice " < br / > it should be noted that this study is currently only conducted in mice, so it can not be directly used in humans, nor can it be used as an endorsement of "anti-aging health care products" However, considering that enampt is also prevalent in humans, researchers hope to carry out follow-up studies as soon as possible to understand the relationship between this molecule and human aging In the most ideal situation, maybe one day, by injecting this molecule, the old can also show the vitality of the young! < br / > reference materials: < br / >  Mitsukuni Yoshida et al., (2019), extracting vehicle contained prompt delays aging and extensions lifespan in mice, cell metabolism, DOI: < br / >  aging delayed in older mice given blood component from young mice, retrieved June 13, 2019, from
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