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Colorectal cancer ( CRC) is the third most common cancer and the fourth most common cause of cancer death
Colorectal cancer ( CRC) is the third most common cancer Colorectal cancer ( CRC) is the third most common cancer
Recently, the team of Yatrik M.
Yatrik M.
The researchers first analyzed related fecal metabolites in mouse models of colorectal cancer caused by different mutations and found that gut microbiota metabolites from healthy mice or humans had growth-inhibitory effects on colorectal cancer cell lines, while colorectal cancer The inhibitory effect of intestinal flora metabolites on colorectal cancer cell lines was weaker in disease model mice or colorectal cancer patients
Through further microbial analysis, the research team found the levels of Lactobacillus reuteri and its metabolite Reuterin in the intestinal flora of colorectal cancer disease model mice or colorectal cancer patients significantly lower than normal
Lactobacillus reuteri is a lactic acid bacterium that exists almost naturally in the intestines of all vertebrates and mammals.
More importantly, the research team found the cytotoxic and growth inhibitory effects of Reuterin.
To further explain the molecular mechanism by which Reuterin inhibits the growth of colorectal cancer cells, the research team combined metabolomic, transcriptomic and proteomic analyses and found that in this process, the oxidative stress response must be and genes downstream of nuclear factor erythroid 2-related factor 2 (NRF2) were up-regulated, and glutathione metabolism was identified as a distinct enriched pathway
Subsequently, the researchers further analyzed the oxidative stress mechanism, indicating that Reuterin inhibits ribosome biosynthesis and downstream protein translation by inducing protein oxidation, thereby inhibiting the growth of colorectal cancer cells
Finally, the research team verified the inhibitory effect of Reuterin on colorectal cancer in model mice
In conclusion, this study shows that the gut flora of healthy individuals, especially Lactobacillus reuteri, can prevent the development of colorectal cancer through the metabolite Reuterin
Original source:
Original source:Hannah N.
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox
balance