echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Cancer Cell: Intestinal flora contributes to the inhibition of colorectal cancer through the metabolite reuterin

    Cancer Cell: Intestinal flora contributes to the inhibition of colorectal cancer through the metabolite reuterin

    • Last Update: 2022-01-22
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Colorectal cancer ( CRC) is the third most common cancer and the fourth most common cause of cancer death


    Colorectal cancer ( CRC) is the third most common cancer Colorectal cancer ( CRC) is the third most common cancer

    Recently, the team of Yatrik M.


    Yatrik M.


    The researchers first analyzed related fecal metabolites in mouse models of colorectal cancer caused by different mutations and found that gut microbiota metabolites from healthy mice or humans had growth-inhibitory effects on colorectal cancer cell lines, while colorectal cancer The inhibitory effect of intestinal flora metabolites on colorectal cancer cell lines was weaker in disease model mice or colorectal cancer patients


    Through further microbial analysis, the research team found the levels of Lactobacillus reuteri and its metabolite Reuterin in the intestinal flora of colorectal cancer disease model mice or colorectal cancer patients significantly lower than normal


    Lactobacillus reuteri is a lactic acid bacterium that exists almost naturally in the intestines of all vertebrates and mammals.


    More importantly, the research team found the cytotoxic and growth inhibitory effects of Reuterin.


    To further explain the molecular mechanism by which Reuterin inhibits the growth of colorectal cancer cells, the research team combined metabolomic, transcriptomic and proteomic analyses and found that in this process, the oxidative stress response must be and genes downstream of nuclear factor erythroid 2-related factor 2 (NRF2) were up-regulated, and glutathione metabolism was identified as a distinct enriched pathway


    Subsequently, the researchers further analyzed the oxidative stress mechanism, indicating that Reuterin inhibits ribosome biosynthesis and downstream protein translation by inducing protein oxidation, thereby inhibiting the growth of colorectal cancer cells


    Finally, the research team verified the inhibitory effect of Reuterin on colorectal cancer in model mice


    In conclusion, this study shows that the gut flora of healthy individuals, especially Lactobacillus reuteri, can prevent the development of colorectal cancer through the metabolite Reuterin


    Original source:

    Original source:

    Hannah N.


    Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox

    balance
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.