Cancer cell: The largest glioblastoma "map" to date, Ding Lituan reveals the biological map that plays a key role in fatal brain tumors

Glioblastoma is a common malignant tumor in the brain that originates from glial cells in the brain.

Glioblastoma is often accompanied by symptoms such as headaches, visual disturbances, and incontinence, which seriously affects the quality of life of patients.

On February 11, 2021, led by Professor Ding Li from Washington University in St.

The study conducted investigation and analysis of 99 patients with glioblastoma, using new technologies such as proteomics, metabolomics, and single-cell sequencing to reveal genes that play an important role in the development of glioblastoma Detailed maps of, proteins, infiltrating cells and signaling pathways.

Glioblastoma is one of the most aggressive and destructive cancers.

In addition, although there are many studies focused on analyzing the genomic characteristics of glioblastoma, there is still very little progress in improving the treatment of patients with this deadly disease.

In this study, the research team conducted a high-resolution and high-depth in-depth analysis of 99 patients with glioblastoma.

Schematic diagram of this study

Researchers have discovered new glioblastoma activating proteins, in which PTPN11 and PLCG1 have more prominent functions.

Then, the research team divided glioblastoma into four different types according to the number and types of immune cells present in glioblastoma:

Type 1 tumors contain a large number of macrophages and a small number of T cells; type 2 tumors have a moderate number of macrophages; type 3 tumors include a large number of T cells and a small number of macrophages; type 4 tumors are "immune deserts".

Glioblastoma can be divided into four different types according to the number and type of immune cells

In this regard, Dr.

Immune features captured by the deep learning model, red represents high immunity, blue represents low immunity

Not only that, the researchers also identified a protein modification in glioblastoma that has not yet been studied-acetylation, which may reveal functional differences between different subtypes of glioblastoma.

From this point of view, abnormal gene expression in glioblastoma will lead to acetylation modification of protein, and the latter will in turn regulate gene expression.

The relationship between histone acetylation and the immune subtypes and signal pathways of glioblastoma

It is worth mentioning that this research is a large-scale international research involving nearly 50 research institutions and hundreds of research authors, and has achieved unprecedented research results-constructing the development process of glioblastoma.

Pathway changes and potential therapeutic targets of glioblastoma species

The leader of the study, Professor Ding Li

Original source:

Liang-Bo Wang, et al.