-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Lung cancer is the malignant tumor
On September 15, 2022, the team of Shen Hongbing of Nanjing Medical University and the team of Hu Zhibin collaborated to publish a research paper
GWAS policy limitations
Academician Shen Hongbing of Nanjing Medical University and Professor Hu Zhibin's team carried out a number of non-small cell lung cancer GWAS in the Chinese group, identified more than 20 genetic variants associated with the onset of NSCLC, and partially revealed the genetic mechanism of lung cancer onset, however, the traditional GWAS strategy based on chip filling still has certain limitations
On the one hand, the chip covers only a subset of genomic variants, and its inference of genotypes of other genomes relies on filling techniques, so accuracy relies on population-matched and more comprehensive and accurate haplotype reference databases, and over the past two decades, genome-wide association studies have strongly linked
On the other hand, the chip filling strategy is only suitable for studying common and low-frequency variants, and the analytical ability of rare pathogenic variants is insufficient
A complete picture of lung cancer pathogenic and rare pathogenic variant genes in the Chinese population
Nanjing Medical University researchers performed large-scale whole-genome sequencing
To study common and low-frequency variations, they first constructed a high-resolution NJLCC haplotype reference panel containing WGS data
Not only that, for the rare loss-of-function variant, the researchers identified BRCA2 and 18 other cancer-susceptibility genes that affected 5.
In addition, the researchers found that the promoter variant of BRCA2 also had a significant effect on NSCLC risk, with a prevalence comparable
Research implications
The researchers conducted in-depth whole genome sequencing of 2984 NSCLC cases and 3020 health-controlled peripheral blood samples, and carried out the largest WGS-based genomics association study
The team of Nanjing Medical University applied large-scale WGS to the genome-wide association study of NSCLC for the first time, constructed a high-quality Chinese group haplotype reference library, newly discovered multiple common and low-frequency susceptibility variants associated with NSCLC, and systematically resolved the rare pathogenic variants in the coding region and regulatory region of NSCLC.
Resources:
This article is intended to introduce medical research advances and cannot be used as a reference for