Cancer cells adapt immune cells

researchers have now discovered new mechanisms for invasive breast cancer cells to avoid the immune system's metastasis or transmission to other parts of the body. This helps develop treatments that target the process, prevent or prevent breast cancer metastasis, and reduce deaths. The paper was published recently in the Journal of Cell Biology.
killer cells, an immune system, can limit the metastasis by inducing cancer cells to die. However, the patient's cancer cells will still metascens, so there must be an unknown escape route.
, Isaac Chan and colleagues at Johns Hopkins University in the United States studied the interaction between natural killer cells and invasive breast cancer cells in real time. It was found that metastatic breast cancer cells can reprogram natural killer cells so that they stop killing cancer cells and instead assist in their metastasis.
identified new strategies for cancer cells to woo the immune system," said Chan, a researcher at the University of The United States. If we can stop or reverse the reprogramming of natural killer cells, it could lead to a new way to stop metastasis and reduce breast cancer mortality. Our
show that natural killer cells selectively target cells that initiate the metastasis process and reveal how cancer cells induce the immune system to assist them. The study also highlights the power of multidisciplinary cancer research. The project teamed up with experts in oncology, cell biology, immunology and biomedical engineering to understand the mechanisms of tumor metastasis. The paper's author, Andrew Ewald, a professor at Johns Hopkins University, said.
with molecular expression spectrum and computational analysis, the researchers were able to map the interactions between each suspected molecule between immune cells and cancer cells, and to identify interactions that might regulate cell-to-cell communication. When researchers block these inhibitory signals, natural killer cells continue to act as "good people" and constantly remove cancer cells. In the paper, the researchers also described new immunotherapy strategies for reversing this reprogramming process in mouse models of breast cancer metastasis.
researchers say other types of cancer may also be involved in the process. Immunotherapy targeting natural killer cells can also be used in a coalition with existing immunotherapy that stimulates T-cells to fight cancer.
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