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    Home > Biochemistry News > Biotechnology News > Cancer Discovery: Gut microbes promote breast cancer

    Cancer Discovery: Gut microbes promote breast cancer

    • Last Update: 2021-01-12
    • Source: Internet
    • Author: User
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    The researchers found that when enterotoxin-fragile bacillus (ETBF) was introduced into the intestines or breast catheters of mice, it always induced the growth and metastasis of tumor cells.
    results were published in the recent issue of Cancer Discovery.
    , a professor of oncology at Johns Hopkins University School of Medicine and senior study author, said that while microbes are known to exist in body parts such as the gastrointestinal tract, nasal passages and skin, breast tissue has only recently been considered sterile.
    Sharma said the study was the first step in demonstrating ETBF's involvement in breast cancer development.
    further research is needed to clarify how ETBF moves throughout the body, whether ETBF is the only driver that directly triggers the transformation of human breast cells, and/or whether the microbiome is also carcinogenic to breast tissue.
    "Despite a number of identified risk factors for breast cancer, such as age, genetic changes, radiation therapy, and family history, there are still significant breast cancers in women who do not have these factors."
    another risk factor, the microbiome, " Sharma said.
    if the microbiome is disturbed, or if it carries cancer-causing microorganisms, it can be considered another risk factor for breast cancer.
    " Sharma and colleagues conducted experiments to study the effects of ETBF.
    , they analyzed clinical data and looked at published studies comparing benign and malignant breast tumors in breast cancer survivors and healthy volunteers with the microbial composition of nipple suction.
    was always detected in all breast cancer tissue samples and in the pap lotions of cancer survivors.
    in the lab, the team fed the ETBF bacteria through the mouth to a group of mice.
    , it breeds in the intestines.
    , within three weeks, the mouse breast tissue undergone changes usually visible in catheter hyperplies (precancerog state).
    In other tests, the researchers found that within two to three weeks of injecting ETBF bacteria directly into the nipples of mice, there were similar signs of growth, and that toxin-exposed cells always showed faster tumor development and more aggressive tumors than unencumbered cells.
    exposed to toxins.
    72 hours of exposure to the toxin retains the toxin's memory and can begin cancer development and form metastases in different mouse models.
    researchers also found that Notch1 β-catenin cell signaling pathlines were associated with promoting the role of EBFT in breast tissue.
    in clinical studies, researchers have begun looking for changes in the microbiome in breast cancer patients to understand how it affects tumor progress and how it responds to treatment.
    "We should definitely strive to maintain a healthy microbiome, including eating healthy and exercise, and maintain the correct body mass index."
    " Source: Gut microbe may promote breast cancers Source: Sheetal Parida et al. A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes, Cancer Discovery (2021). DOI: 10.1158/2159-8290.CD-20-0537。
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