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    Home > Active Ingredient News > Digestive System Information > Cancer Discovery (IF=39) Wan Fengyi's team discovered the underlying mechanism of bacterial gene toxins driving colon tumors

    Cancer Discovery (IF=39) Wan Fengyi's team discovered the underlying mechanism of bacterial gene toxins driving colon tumors

    • Last Update: 2022-01-10
    • Source: Internet
    • Author: User
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    Editor’s note iNature is China’s largest academic public account.
    It is jointly created by a team of doctors from Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
    The iNature talent public account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
    .

    The chronic and low-grade inflammation associated with persistent bacterial infections in iNature is related to the development of colon tumors; however, the impact of temporary and self-limiting infections on bacterial-driven colon tumors remains a mystery
    .

    On December 20, 2021, the Wan Fengyi team of Johns Hopkins University published an online research paper titled "Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis" in Cancer Discovery (IF=39).
    The research report UshA is A new type of attaching/effacing (A/E) pathogen gene toxin, including human pathogen enteropathogenic Escherichia coli, enterohemorrhagic Escherichia coli and its mouse equivalent Citrobacter rodentium (CR)
    .

    UshA has the activity of catalyzing the direct DNA digestion of histidine-aspartic acid dimer
    .

    UshA is injected into host cells through the Type III secretion system (T3SS), which triggers DNA damage and initiates tumorigenic transformation during infection in vitro and in vivo
    .

    In addition, UshA plays an indispensable role in CR infection in genetically susceptible ApcMinΔ716/+ mice and in accelerating colon tumorigenesis
    .

    In general, the results of the study show that UshA, as a bacterial T3SS-dependent gene toxin, plays a key role in promoting transient and non-invasive bacterial infections in mice and accelerating the occurrence of colon tumors
    .

    Bacterial infections have become an important environmental factor leading to the global cancer burden
    .

    Several bacteria that are highly associated with human colon tumors, including enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, and E.
    coli strains containing polyketide synthase genome islands, have recently been shown to accelerate the development of colon tumors
    .

    These findings emphasize the key role of persistent infection and chronic inflammation in bacterial-driven colon tumorigenesis
    .

    As the main pathogens of diarrheal diseases, human pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic Escherichia coli (EHEC) and their mouse equivalent Citrobacter rodentium (CR), through the formation of attachment and elimination (A/E) intestinal epithelium Lesions
    .

    Although early evidence indicates tumorigenic potential, the impact of non-invasive infection of A/E pathogens on bacterial-promoted colon tumorigenesis and its underlying mechanism remain unclear
    .

    The study reports that UshA is a new type of attaching/effacing (A/E) pathogen gene toxin, including human pathogen enteropathogenic Escherichia coli, enterohemorrhagic Escherichia coli and its mouse equivalent Citrobacter rodentium (CR )
    .

    UshA has the activity of catalyzing the direct DNA digestion of histidine-aspartic acid dimer
    .

     UshA is injected into host cells through the Type III secretion system (T3SS), which triggers DNA damage and initiates tumorigenic transformation during infection in vitro and in vivo
    .

    In addition, UshA plays an indispensable role in CR infection in genetically susceptible ApcMinΔ716/+ mice and in accelerating colon tumorigenesis
    .

    In general, the results of the study show that UshA, as a bacterial T3SS-dependent gene toxin, plays a key role in promoting transient and non-invasive bacterial infections in mice and accelerating the occurrence of colon tumors
    .

    Reference message: https://cancerdiscovery.
    aacrjournals.
    org/content/early/2021/12/18/2159-8290.
    CD-21-0912
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