Cancer Res: Scientists identify potential new cancer targets
Last Update: 2020-06-17
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, June 9, 2020 /PRNewswire/ --In a recent study published in the international journalCancer Research, scientists from Vanderbilt University and others have discovered a potential new cancer targetPicture Source: CC0 Public Domain
Because of the associated biological mechanisms, researchers do not yet know the key role of conversion growth factor beta (TGF-beta) in cancer progression; for many years, researcher Sergey Novitskiy and others have been studying how nucleotides promote TGF-beta activity, including itstumor-driven effects, which are essential for a variety of cell functions;this study, the researchers found that the expression of adenosine receptors is closely related to the production of collagen, but also with the lower mortality rate of patients
with triple-negativebreast cancer, and that adenosine itself has no effect on collagen production, but it weakens the normal TGF-beta response in fibroblasts, thus promoting the atypical formation of extracellular matrix, which in turn supports the growth and metastasis oftumorsthe final researchers say these effects may be mediated by A2b rather than A2a adenosine receptors, suggesting that these adenosine receptors may be valuable targets for future scientists to develop anticancer therapies(BioValleyBioon.com)original origins:Georgii Vasiukov, Tatiana Novitskaya, Andries Zijlstra, et al.
Myeloid cell-derived TGF-beta signaling regulates eCM deposition in mammary carcinoma via adenosine-dependent,Cancer Research(2020)doi: 10.1158/0008-5472.CAN-19-3954
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