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Cancers: Efficacy and safety of radiotherapy combined with S-1 in the treatment of head and neck tumors: from a Meta analysis

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor, accounting for about 3.
3% of all cancer cases
.

Squamous cell carcinoma of the head and neck is generally treated with concurrent radiotherapy and chemotherapy after surgery, and traditional chemotherapy drugs often cause a variety of side effects

Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor, accounting for about 3.

Research searches the PubMed, Web of Science, Embase, and Cochrane databases until February 10, 2021
.

The random effects model was used to evaluate the tumor response, local control rate (LCR), overall survival (OS) and adverse events (AEs) of S-1 combined with radiotherapy for HNSCC

Research searches the PubMed, Web of Science, Embase, and Cochrane databases until February 10, 2021

research summary

The objective response rate (ORR) can be extracted from 6 studies, and the comprehensively calculated ORR is 86.
3% (95%CI, 60.
3-96.
3; I ² = 85.
2, p <0.
001)
.

Analysis of the location of the primary tumor showed that the ORR of oral cancer and laryngeal cancer was significantly different (46% vs 97%, I ² = 67.

The objective response rate (ORR) can be extracted from 6 studies, and the comprehensively calculated ORR is 86.

ORR, CBR and LCR-3

Oral cancer and laryngeal cancer ORR, CBR, LCR-3, OS-3 and grade 3/4 adverse events

12 studies can calculate the 3-year OS, and the comprehensive 3-year OS is 84.
0% (95% CI, 71.
4-91.
7; I ² = 79.
6, p <0.
001)
.

There was a statistically significant difference in OS-3 between oral cancer and laryngeal cancer (60.

12 studies can calculate the 3-year OS, and the comprehensive 3-year OS is 84.

OS-3 and grade 3/4 adverse events

In summary, the meta-analysis showed that S-1 combined with radiotherapy for head and neck tumors showed good tumor remission and survival, especially in laryngeal cancer, and the toxicity was tolerable
.

Therefore, it is necessary to carry out a large randomized controlled study (RCT) to confirm the efficacy and safety of the combination of the two

Original source:

Shih, H.

Shih, H.
-S.
; J hou, H.
-J.
; Ou, Y.
-H.
; et al.
The Efficacy and Adverse Events in Patients with Head and Neck Cancer Following Radiotherapy Combined with S-1 Therapy: A Meta-Analysis.
Cancers 2021, 13, 2971.
https://doi.
org/ 10.
3390/cancers13122971.
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