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Of colorectal cancer (CRC) is the world's common digestive tract
Of colorectal cancer (CRC) is the world's common digestive tract
From May 28, 2015 to August 11, 2020, a total of 114 CRC patients and 67 healthy people were included in the study
From May 28, 2015 to August 11, 2020, a total of 114 CRC patients and 67 healthy people were included in the study
Compared with healthy people, the level of sSIGLEC5 in the plasma of CRC patients was significantly increased, with a statistical difference (p ≤ 0.
Comparison of the level of CRC and healthy people
Then analyze the levels of sSIGLEC5 in patients with different stages, and it can be found that as the stage increases, the level of sSIGLEC5 is higher, and it is positively correlated with the stage of the patient (Pearson r = 0.
Then analyze the levels of sSIGLEC5 in patients with different stages, and it can be found that as the stage increases, the level of sSIGLEC5 is higher, and it is positively correlated with the stage of the patient (Pearson r = 0.
Different stages and correlation analysis
In order to distinguish death and survival patients, the investigator performed ROC curve analysis, and the AUC was 0.
In order to distinguish death and survival patients, the investigator performed ROC curve analysis, and the AUC was 0.
ROC
Wald regression model analyzes whether the following variables are independent prognostic factors: age, gender, stage, treatment, tumor size, lymph node metastasis, lymphatic invasion, nerve invasion, surgical margin, CEA, grade and sSIGLEC5
Wald regression model analyzes whether the following variables are independent prognostic factors: age, gender, stage, treatment, tumor size, lymph node metastasis, lymphatic invasion, nerve invasion, surgical margin, CEA, grade and sSIGLEC5
Regression analysis of prognostic factors
Kaplan–Meier curve for survival analysis, the overall survival (OS) of patients with high levels of sSIGLEC5 and lower levels was significantly shortened (HR=15.
subsistence analysis
In summary, the study shows that water-soluble SIGLEC5 (sSIGLEC5) is a prognostic indicator for patients with colorectal cancer
.
.
This study shows that water-soluble SIGLEC5 (sSIGLEC5) is a prognostic indicator for patients with colorectal cancer
.
The study showed that water-soluble SIGLEC5 (sSIGLEC5) is a prognostic indicator for patients with colorectal cancer
.
Original source:
Original source:Montalbán-Hernández, K.
; Cantero-Cid, R.
; Lozano-Rodríguez, R.
; et al.
Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients.
Cancers 2021, 13, 3896.
https://doi.
org /10.
3390/cancers13153896.
; Cantero-Cid, R.
; Lozano-Rodríguez, R.
; et al.
Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients.
Cancers 2021, 13, 3896.
https://doi.
org /10.
3390/cancers13153896.
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