Cansino new crown vaccine: 2 doses of inactivated and 1 dose of inhalation, the level of neutralizing antibodies increased by up to 300 times

On October 15, 2021, the 21st China Biological Products Annual Conference was held in Nanjing as scheduled.
Dr.
Zhu Tao, Chief Scientific Officer of Cansino Biotech Co.
, Ltd.
, brought a presentation entitled "The R&D Process of Adenovirus Vector Vaccine-How to Race Against Viruses" Keynote speech
.

The speech was divided into four chapters, including the overall overview of global new crown vaccine research and development, the research and development results and clinical research progress of Cansino adenovirus vector new crown vaccine, the interpretation of clinical data of Keweisha® booster immunization, and the immunization of Keweisha® inhaled dosage form Mechanism and advantages
.

Cansino adenovirus vector vaccine is the result of science and cooperation.
Dr.
Tao Zhu started with "The new crown vaccine is a miracle in the history of human vaccines", clearly and vividly combing the overall overview of the global new crown vaccine research and development, focusing on the rapid development of the new crown vaccine Interpretation of the efficiency of supervision, the richness of pipelines, the variety of types, and the outstanding results
.

In the second chapter, Dr.
Tao Zhu made it clear: Cansino adenovirus vector vaccine is the result of science and cooperation
.

The research results show that one dose of Cansino adenovirus vector vaccine Keweisha® can produce significant humoral and cellular immune responses, realizing double protection for the human body
.

After 14 days, the overall protection rate was 68.
83%, and the critical protection rate was 95.
47%
.

As of a few days ago, Kevisa® has obtained emergency use approvals in Mexico, Chile, Ecuador, Argentina, Hungary, Pakistan, Indonesia, Kyrgyzstan and other countries, and obtained conditional marketing permits in Malaysia.
It has made contributions to the global fight against the new crown epidemic and is a vaccine for China.
A solid step has been taken towards the world
.

Regarding the use of adenovirus vector technology to develop new coronavirus vaccines, Dr.
Tao Zhu stated that adenovirus vector technology is safe and mature and has been widely used.
Its advantages are: (1) a wide range of adenovirus hosts; (2) human adenoviruses are widespread, and Respiratory tract infections are related and have low pathogenicity to humans; (3) Adenovirus recombinant vector construction technology is relatively mature, and many vaccines using adenovirus as a carrier have been successfully marketed; (4) Adenovirus has the function of immune adjuvant and can Stimulate the body's natural immune response; (5) The production process platform has high versatility and can quickly respond to new crown variants
.

Dr.
Zhu Tao introduced that there are currently 17 clinical trials for the vaccine that have been launched or are in the process of being launched to verify the safety and effectiveness of the vaccine as fully as possible
.

In addition, Cansino has also actively and effectively explored the expansion of vaccine production capacity, and actively demonstrated the promotion of localization of production equipment
.

Kevisa® enhancement is a plan based on scientific and clinical data.
Dr.
Tao Zhu emphasized that the various vaccines that have been conditionally marketed in China have made significant contributions to the prevention and control of the epidemic
.

With the passage of time and the influence of mutant strains, the protective efficacy of the vaccine has decreased to varying degrees
.

Facing the challenge of epidemic prevention and control and the urgent need to open the country, boosting immunization with more protective vaccines has become necessary and urgent
.

Dr.
Tao Zhu said: “The race between vaccines and time is not over.
Kevisa® enhancement is a plan based on scientific and clinical data
.

” In the speech, Dr.
Tao Zhu used research data to show that the strong endurance of antibodies and cellular immunity are The characteristics of adenovirus vector vaccines
.

Clinical data showed that the level of neutralizing antibody of adenovirus vector vaccine only decreased by 1.
4 times after 6 months of vaccination, and the level of neutralizing antibody could increase by 8 times after 6 months of initial vaccination, and the level of antibody continued to be high within one year
.

(3-6 months after vaccination with two doses of inactivated vaccines, use Keweisha® to boost IgG antibodies by about 200 times, while vaccination with inactivated vaccines increases by 30 times
.

The difference between the two is about 8 times, and the difference in neutralizing antibodies is about 6 times) According to the results of heterologous sequential enhancement animal experiments released by the China Inspection Institute, the advantage of sequential enhancement of adenovirus vector vaccine is obvious
.

The data shows that after two doses of inactivated Covid-19 vaccine, boosted with different vaccines, the adenovirus vector vaccine has the best boost effect, the mRNA vaccine effect is close to the adenovirus vector, and the inactivated or subunit vaccine boost is significantly lower than that of adenovirus and mRNA.
Vaccine, the level of neutralizing antibody is nearly 10 times different
.

Keweisha® inhalation dosage form stimulates respiratory tract mucosal immunity and realizes the "most natural care" for the human body from the route of administration.
With regard to Keweisha® inhalation dosage form, Dr.
Tao Zhu indicated that this is an innovation in vaccination and the only triple protection mechanism Vaccine
.

Dr.
Tao Zhu said that since the new coronavirus is mainly infected and spread through the respiratory tract, COVID-19 is a respiratory disease, and it is very important to establish mucosal immune protection, which indicates that mucosal vaccination (such as intranasal, lung, oral) may be possible Better than vaccination
.

When talking about the immune mechanism of nebulized inhaled vaccines, Dr.
Tao Zhu said: "The design concept of vaccines is to train the body's immune memory function by imitating the natural infection of the virus, which should also include the simulation of the route of infection
.

Currently on the market vaccines They are all intramuscular injections and do not simulate the natural route of infection at all
.

As a respiratory infectious disease, the establishment of mucosal immunity is particularly important for the protection of new coronary pneumonia.
This suggests that vaccines through mucosal immunity may have unique advantages over non-mucosal administration
.

" The results of animal experiments show that the mucosal immunity generated by Cansino inhaled adenovirus vector vaccine can completely eliminate the new coronavirus in the lungs and turbinates
.

So what are the characteristics of mucosal vaccines? Dr.
Zhu Tao said that mucosal immunity is the first battlefield against viral infections
.

The effective weapons of mucosal immunity are secreted IgA dimers, as well as T cells and B cells that are deployed and resided by antigens
.

Secreted IgA can provide additional protection in the respiratory mucosa (especially the upper respiratory tract) in addition to IgG, and neutralize the new coronavirus earlier and more effectively; the resident memory B cells and T cells activated in the respiratory mucosa are better than system memory cells Encounter the antigen earlier, react faster, hinder virus replication, and reduce virus shedding and spread
.

Heterogeneous sequential enhancement with nebulized inhalation dosage form is more advantageous than homologous enhancement.
In his speech, Dr.
Tao Zhu shared the latest clinical research progress of Keweisha® inhalation dosage form
.

The study found that 6 months after inoculation of 2 doses of inactivated vaccines, one dose of Kevisa® inhaled dosage form was sequentially boosted, and the level of neutralizing antibody was 250-300 times higher than before the boost; if the homologous boosted 1 dose of inactivated vaccine , The level of neutralizing antibody was 30 times higher than before the boost
.

It can be seen that the inhaled adenovirus vector new crown vaccine for heterologous sequential enhancement is more advantageous than the third injection of inactivated vaccine
.

Sequential vaccination by inhalation can induce extremely high levels of IgG antibodies and cellular immune responses.
The increase in antibodies boosted by inhalation is about 7-8 times that of a dose of inactivated vaccine
.

(See the figure below, editor's note) (Sequential immunization with nebulized inhalation can induce a significant humoral immune response, editor's note) In addition, sequential inhalation immunization can obtain high-efficiency neutralizing antibodies against prototype strains, Alpha, Beta, Gamma, and Delta strains
.

As Dr.
Zhu Tao said, the race between vaccines and time is not over yet, and it is our common expectation to end the epidemic as soon as possible
.

The CanSino adenovirus vector vaccine is the result of science and cooperation, and the Kevisa® booster immunization program is a program based on scientific and clinical data.

.

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