Cao Xuetao's team revealed a new mechanism for natural immune response against bacteria

, a member of the Chinese Academy of Engineering and president of Nankai University, published new findings in the field of natural immunity and inflammation online October 12. The study found that natural immune cell migration is essential for interferon subject assembly and expression on the surface of cell membrane, which enables immune cells to effectively sense interferon action and activate natural immune function to eliminate bacterial infections in cells. The discovery reveals a new mechanism of natural immune response regulation from the perspective of cytokine subjects, and also puts forward a new way of thinking for the prevention and treatment of intracellular bacterial infection diseases of TB bacteria.
immune cells, such as macrophages, are activated by type II interferons to remove bacteria from intracellular infections. After the invasion of the perceived pathogen, macrophages and so on swim out of the blood and migrate to the infected site play a key role in its natural immune function, but it is not clear how cell migration affects its natural immune function against endocytobacteria.
With funding from the Medical and Health Innovation Project of the Chinese Academy of Medical Sciences and the National Natural Science Foundation of China, Cao Xuetao and Dr. Xu Xiaoqing of the Immunotherapy Research Center of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences have found that macrophages interact with the adhesive molecule E-selectin on the surface of vascular endocrine cells during migration, activating macrophage tyrosine kinase molecules, and then performing subi2 on type II interferon in the cells. Site selective phosphatization, resulting in phosphatization after the subject sub-base 2 and transport protein binding, to promote its transport process from the golkyl body to the cell membrane, and finally in the cell membrane with another interferon subject sub-base 1 binding, assembly into functional interferon subject, so that macrophages can respond to the presence of interferon outside, play its antibacterial role.
This study is of great significance for clarifying the dynamic process of cell membrane receptor expression, especially the role of protein modification in the process of receptor dynamic expression on the surface of cell membrane, and also for the study of other cytokine receptors and immunocytosuppressive and active receptors. From the new perspective of cytokine-like membrane expression regulation to study whether natural immune cells can respond effectively and function, it provides potential targets and ideas for immunotherapy of chronic infectious diseases, inflammatory diseases and tumors. (Source: Science Network Zhang Siwei)